Pathological sub-analysis of a multicenter randomized controlled trial of tonsillectomy combined with steroid pulse therapy versus steroid pulse monotherapy in patients with immunoglobulin A nephropathy

Clinical and Experimental Nephrology
Ritsuko KatafuchiIgA nephropathy Study Group in Japan

Abstract

The IgA nephropathy (IgAN) Study Group in Japan conducted a multicenter, randomized, controlled trial of tonsillectomy with steroid pulse therapy (TSP) versus steroid pulse monotherapy in patients with IgAN (UMIN Clinical Trial Registry Number; C000000384). The effects of therapies in relation to pathological severity were analyzed in this study. The patients with IgAN, urinary protein 1.0-3.5 g/day, serum creatinine of 1.5 mg/dl or less were randomly assigned to receiving TSP (Group A) or steroid pulses alone (Group B). The primary endpoint was the disappearance of proteinuria and/or hematuria. Twenty-six biopsies in Group A and 33 in Group B were available. The histological grades (HG) according to the percentage of glomeruli with crescent or sclerosis and the Oxford classification were analyzed. The patients in Group A had a 4.32- to 12.1-fold greater benefit of disappearance of proteinuria and 3.61- to 8.17-fold greater benefit of clinical remission (disappearance of proteinuria and hematuria) than those in Group B in patients with HG2-3, acute lesions (cellular or fibrocellular crescent) affecting more than 5 % of glomeruli, chronic lesions (fibrous crescents or sclerosis) affecting more than 20 % and S1. In contrast, odds...Continue Reading

References

Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L P BartosikD C Cattran
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·O HottaY Taguma
Jan 5, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Philip Kam Tao LiFernand Mac-Moune Lai
Oct 31, 2003·Clinical and Experimental Nephrology·Yasuhiko TominoUNKNOWN Special Study Group (IgA Nephropathy) on Progressive Glomerular Disease
Dec 25, 2003·Journal of the American Society of Nephrology : JASN·Claudio PozziFrancesco Locatelli
Apr 28, 2006·Kidney International·G B Appel, M Waldman
Aug 26, 2006·Nature Clinical Practice. Nephrology·Francesco LocatelliClaudio Pozzi
May 30, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Hiroyuki KomatsuKazuo Kitamura
Jul 23, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ritsuko KatafuchiHideki Hirakata
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Apr 29, 2009·The Tohoku Journal of Experimental Medicine·Yukihiko KawasakiMitsuaki Hosoya
Dec 29, 2010·Clinical Reviews in Allergy & Immunology·Hsin-Hui YuBor-Luen Chiang
Sep 29, 2011·Journal of the American Society of Nephrology : JASN·Hitoshi SuzukiBruce A Julian
Jun 12, 2012·Journal of Nephrology·Tetsuya KawamuraUNKNOWN Study Group Special IgA Nephropathy
Mar 23, 2013·Clinical and Experimental Nephrology·Keiichi MatsuzakiYasuhiko Tomino
Mar 7, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tetsuya KawamuraUNKNOWN Special IgA Nephropathy Study Group

❮ Previous
Next ❯

Citations

Oct 11, 2016·International Urology and Nephrology·Jiayu DuanZhangzuo Liu
Mar 13, 2020·The Cochrane Database of Systematic Reviews·Patrizia NataleGiovanni Fm Strippoli
Feb 18, 2021·Clinical and Experimental Nephrology·Chisako KamanoUNKNOWN Japan IgA nephropathy prospective cohort Study Group
Jun 9, 2021·Clinical and Experimental Nephrology·Shota OguraKosaku Nitta

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
urine collection
biopsy

Software Mentioned

TSP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.