Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas

The American Journal of Surgical Pathology
N V AdsayDavid Klimstra

Abstract

Although general characteristics of intraductal papillary mucinous neoplasms (IPMNs) and their delineation from other pancreatic tumors have been well established, several issues regarding their biology and management remain unresolved. It has been noted briefly by us and other authors that there are different types of papillae in IPMNs; however, their frequency, biologic significance, and clinical relevance are unknown. In this study, the association of different papillary patterns with clinical, pathologic, and biologic parameters was studied in 74 IPMNs, and the expression profile of CDX2 (a specific marker and one of the key determinants of intestinal "programming," and a tumor suppressor) was determined immunohistochemically in addition to MUC1 (a marker of an "aggressive" phenotype in pancreatic neoplasia) and MUC2 ("intestinal type mucin," a marker of the "indolent" phenotype, and a tumor suppressor). The patterns of papillae identified and their association with these parameters were as follows: 1) The intestinal-type (Yonezawa's dark-cell type), similar to villous adenomas, was seen in 26 of 74 (35%) cases. The majority harbored carcinoma in situ (85%) or borderline atypia (15%). They tended to be large (mean, 5.5 cm)....Continue Reading

References

Sep 11, 1991·The Journal of Clinical Investigation·N W ToribaraY S Kim
Jul 1, 1991·Cancer·M YamadaY Tsukamoto
Apr 15, 1994·International Journal of Cancer. Journal International Du Cancer·M A HollingsworthD R Mack
May 1, 1996·Japanese Journal of Cancer Research : Gann·Y MakiguchiK Imai
Aug 1, 1996·The American Journal of Surgical Pathology·N V AdsayD S Klimstra
Sep 2, 1998·The International Journal of Biochemistry & Cell Biology·A AllenJ P Pearson
Apr 16, 1999·American Journal of Surgery·M SiechH G Beger
Oct 21, 2000·Gastroenterology·D G SilbergP G Traber
Nov 4, 2000·International Journal of Cancer. Journal International Du Cancer·S SatohM A Hollingsworth
Jan 6, 2001·The American Journal of Surgical Pathology·N V AdsayD S Klimstra
Mar 2, 2002·Science·Anna VelcichLeonard Augenlicht
Mar 5, 2002·Gastroenterology·Debra G SilbergKlaus H Kaestner
Mar 27, 2002·The American Journal of Surgical Pathology·J LüttgesG Klöppel
Jun 8, 2002·Biochemical and Biophysical Research Communications·Hiroyuki MutohKentaro Sugano
Sep 28, 2002·Journal of Hepato-biliary-pancreatic Surgery·Suguru YonezawaEiichi Sato
Oct 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·N Volkan AdsayDavid S Klimstra
Oct 26, 2002·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Carlos Fernandez-del Castillo
Oct 26, 2002·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·L William Traverso
Feb 1, 2003·Biochemical and Biophysical Research Communications·Hiroshi YamamotoYasuhito Yuasa
Feb 1, 2003·Journal of Gastroenterology·Akashi EdaKentaro Sugano
Mar 26, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michael G SarrPatrick C Freeny
Jun 17, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jutta LüttgesGünter Klöppel
Aug 2, 2003·Nature Reviews. Cancer·Yasuhito Yuasa
Aug 30, 2003·The Journal of Biological Chemistry·Takao HinoiEric R Fearon
Sep 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher A MoskalukHenry F Frierson
Oct 25, 2003·The American Journal of Surgical Pathology·Roy W PhillipsChristopher A Moskaluk
Nov 15, 2003·Journal of Cancer Research and Clinical Oncology·Tsutomu MizoshitaMasae Tatematsu

❮ Previous
Next ❯

Citations

Dec 14, 2004·Der Pathologe·G KlöppelJ Lüttges
Sep 13, 2011·Der Pathologe·B Sipos, T Henopp
Feb 6, 2013·Der Pathologe·L VeitsA Agaimy
Feb 3, 2005·Virchows Archiv : an International Journal of Pathology·Claudio SorioAldo Scarpa
Jul 16, 2005·Virchows Archiv : an International Journal of Pathology·Sönke DetlefsenGünter Klöppel
Aug 10, 2005·Virchows Archiv : an International Journal of Pathology·Toru FurukawaSuguru Yonezawa
Sep 28, 2007·Virchows Archiv : an International Journal of Pathology·Snezana Andrejevic-BlantGünter Klöppel
May 24, 2007·Journal of Hepato-biliary-pancreatic Surgery·Kyoichi Takaori
May 24, 2007·Journal of Hepato-biliary-pancreatic Surgery·Ralph H HrubanMichael Goggins
Oct 25, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·N Volkan Adsay
Jul 3, 2013·Best Practice & Research. Clinical Gastroenterology·Giuseppe ZamboniAnne Marie Lennon
Jul 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Takeo NittaYoshihiro Matsuno
Jul 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·M MonzenK Shiratori
Nov 28, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Atsuhiro MasudaHiromu Kutsumi
Jan 13, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kohei NakataMasazumi Tsuneyoshi
Nov 26, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kosuke TsutsumiMasao Tanaka
Aug 9, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michelle D ReidVolkan Adsay
Apr 16, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Toru FurukawaAkira Horii
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Markus KosmahlGünter Klöppel
May 9, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·N Volkan Adsay
Mar 31, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hiroshi YamaguchiMasazumi Tsuneyoshi
Mar 9, 2011·Nature Reviews. Gastroenterology & Hepatology·Hanno MatthaeiAnirban Maitra
Mar 7, 2012·Nature Reviews. Gastroenterology & Hepatology·Jens WernerMarkus W Büchler
Aug 28, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Kee-Taek JangGeunghwan Ahn
Apr 16, 2005·The American Journal of Surgical Pathology·Yoshifuku NakayamaSeiyo Ikeda
Dec 7, 2005·The American Journal of Surgical Pathology·Edward B StelowChristopher A Moskaluk
Nov 24, 2006·The American Journal of Surgical Pathology·Shinichi BanMichio Shimizu
Jan 27, 2007·The American Journal of Surgical Pathology·Mohammad OthmanN Volkan Adsay
Dec 3, 2009·Pancreas·Yoshihiro MiyasakaMasao Tanaka
Sep 25, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Barbara ChadwickJoseph Holden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.