PMID: 3103049Feb 1, 1987Paper

Pathologically induced alterations in the dimensions of the hepatic portal vasculature of mice infected with Schistosoma mansoni

S M McHughR A Wilson


Alterations in the hepatic portal vasculature of NMRI mice infected with Schistosoma mansoni were assessed using a microsphere injection technique. The accumulation of eggs in the livers of infected mice and the development of portal hypertension were closely related to the worm pair burden during the first 15 weeks of infection. Individual variation between mice harbouring identical patent worm pair burdens was partially explained by the reduced fecundity of females from sexually biased infections. As eggs accumulated in the liver and portal hypertension increased, the number of injected microspheres escaping from the hepatic portal system rose in rank order of diameter from 9 microns through 15 microns and 25 microns to 50 microns. There was a strong correlation between the numbers of parasite eggs in the lungs and injected microspheres recovered from the lungs. The pattern of detection of microspheres in the lungs indicated a progressive increase in diameter of intra-hepatic porta-systemic connexions, followed by development of large-bore extra-hepatic collateral vessels. An accurate temporal profile of the pathological state of the host and the extent of collateral vessel formation was obtained. Injection of 141-Ce-labelled...Continue Reading


Sep 1, 1972·The American Journal of Tropical Medicine and Hygiene·E H BlochK S WARREN
Jan 1, 1968·Archives of Surgery·R E MaddenM Schwartz
Feb 1, 1983·Experimental Parasitology·D A Dean
Nov 1, 1981·The American Journal of Tropical Medicine and Hygiene·Z A Andrade, P A Brito
Jul 1, 1959·The American Journal of Tropical Medicine and Hygiene·W B DEWITT, K S WARREN
Mar 1, 1963·Journal of Applied Physiology·A W CHEEVER, K S WARREN
Sep 1, 1964·Transactions of the Royal Society of Tropical Medicine and Hygiene·A W CHEEVER, K S WARREN


Mar 7, 2009·Parasitology·R A Wilson
Sep 30, 2008·PLoS Neglected Tropical Diseases·R A WilsonPatricia S Coulson
Dec 1, 1989·Parasitology·Patricia S Coulson, R A Wilson
Dec 8, 2010·Expert Review of Anti-infective Therapy·Ewa KolosionekGhazwan Butrous
Aug 1, 1992·Current Opinion in Immunology·A R Capron
Aug 27, 2015·American Journal of Respiratory and Critical Care Medicine·Alexi CrosbyNicholas W Morrell
Jan 1, 1990·Parasitology Today·R A Wilson
Feb 20, 2007·Memórias do Instituto Oswaldo Cruz·Patricia S Coulson, Thomas M Kariuki

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.