[Pathology along the liver sinusoids: endothelial and perisinusoidal findings].

Der Pathologe
H P FischerH Zhou

Abstract

Sinusoidal alterations unrelated to primary hepatocellular damage present without characteristic clinical findings and in these cases the liver biopsy is particularly important. Capillarization of sinusoids is characterized by closing of fenestration, formation of a basal membrane and by the expression of CD34 and is typical for active cirrhosis. In nodular regeneratory hyperplasia, capillarization indicates a local or general disturbance of perfusion. In large regenerative nodules, focal nodular hyperplasia and liver cell adenoma CD34-positive capillaries reflect afferent parts and CD34-negative sinusoids the efferent parts of the parenchymal vascular bed. HCC generally have a completely capillarized CD34-positive vascular bed. Hepatic angiosarcomas and epithelioid hemangioendotheliomas can be easily overseen in liver biopsies, if they spread along the sinusoids without detoriation of the acinar architecture and without significant alteration of the surrounding liver cell plates. Toxic damage of endothelial cells, post-sinusoidal stasis and sinusoidal hyperperfusion are the underlying pathogenetic principles of sinusoidal injury. Rupture and loss of the perisinusoidal reticulin fibres lead to peliosis hepatis. In these cases l...Continue Reading

References

Nov 1, 1976·Gut·R K TandonR R Arora
Jun 1, 1991·Archives of Surgery·S R HaywardA M Ledgerwood
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·M E LafonC Balabaud
Apr 1, 1987·Liver·M BrugueraC Rozman
Aug 1, 1987·Journal of Clinical Gastroenterology·D RouxC Balabaud
Feb 1, 1987·Digestive Diseases and Sciences·P BonnetD Franco
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M MicanD D Metcalfe
Dec 1, 1994·The American Journal of Medicine·T E KowalskiP F Malet
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·A Martinez-Hernandez, P S Amenta
Jun 16, 2001·Virchows Archiv : an International Journal of Pathology·I TheuerkaufH P Fischer
Apr 1, 1958·The Journal of Pathology and Bacteriology·G R CAMERON, S MUZAFFAR HASAN
Nov 2, 2004·Human Genetics·T G W LetteboerJ K Ploos van Amstel
Mar 11, 2005·Current Opinion in Critical Care·O N Tucker, N Heaton
May 17, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Liron PantanowitzSteven R Tahan
Aug 9, 2005·Human Pathology·Narasimhan AgaramThomas A Godwin

❮ Previous
Next ❯

Citations

Feb 6, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gro Linno Willemoe, Ben Vainer

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Bartonellosis

Bartonellosis is an infection caused by bacteria in the genus Bartonella and can present as a variety of diseases depending on the organism involved. While asymptomatic infection has been reported, immunocompromised individuals are more susceptible to severe infection. Find the latest research on bartonellosis here.

Adenoma, Liver Cell

Liver Cell Adenoma or hepatic adenoma is a rare benign tumor. It is associated with birth control use or pregnancy. Discover the latest research on Liver Cell Adenoma here.