PMID: 2125143Jan 1, 1990Paper

Pathology and cell proliferation induced by intra-nasal instillation of aldehydes in the rat: comparison of glutaraldehyde and formaldehyde

Toxicologic Pathology
M B St ClairK T Morgan

Abstract

The relative toxicities of formaldehyde and glutaraldehyde to the rat nasal epithelium were determined following intra-nasal instillation of aqueous solutions of these compounds into one nostril of male Fischer 344 (F-344) rats. Lesions identical in appearance to those resulting from acute inhalation exposure to formaldehyde were induced by both compounds in a concentration-dependent manner. Treatments included India ink or 1 M methylene blue (for instillation deposition studies); sterile saline (vehicle control); 40, 200, 400, and 800 mM formaldehyde; and 10, 20, and 40 mM glutaraldehyde. Dye-treated rats were sacrificed immediately, and nasal passages were examined to determine the localization of instilled materials. Three days after treatment, all other animals received a single ip injection of 5-bromo-2'-deoxyuridine 2 hr prior to sacrifice, and the nasal passages were prepared for histopathology and cell proliferation studies. While sterile saline and 10 mM glutaraldehyde induced no significant epithelial changes, 20 and 40 mM glutaraldehyde induced extensive lesions in the treated side of the nose. Aldehyde-induced lesions included inflammation, epithelial degeneration, respiratory epithelial hypertrophy, and squamous me...Continue Reading

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Citations

Jan 1, 1991·Environmental and Molecular Mutagenesis·M B St ClairL Recio
Mar 1, 1994·Toxicology Letters·D ZissuP Bonnet
Mar 30, 2005·Mutation Research·Errol ZeigerPamela Spencer
Apr 8, 2003·Toxicology·Susan D HesterDouglas C Wolf
Jun 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·T M Monticello, K T Morgan
Dec 1, 1993·Environmental Health Perspectives·T M MonticelloK T Morgan
Apr 14, 2006·Journal of Occupational Health·Tomoko Takigawa, Yoko Endo
Sep 1, 1991·Experimental Lung Research·M BonnefoiK T Morgan
Jan 11, 1992·Critical Reviews in Toxicology·R O BeauchampF W Kari
Dec 24, 1998·Toxicologic Pathology·K M Walsh, C L Courtney
Aug 1, 1995·Endodontics & Dental Traumatology·P J Waterhouse
Aug 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wichchulada ChimpibulKazuaki Matsumura

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