Pathology, clinical presentations, and outcomes of C1q nephropathy

Journal of the American Society of Nephrology : JASN
Alenka VizjakJ Charles Jennette

Abstract

C1q nephropathy is an uncommon glomerular disease with characteristic features on immunofluorescence microscopy. In this report, clinicopathologic correlations and outcomes are presented for 72 patients with C1q nephropathy. The study comprised 82 kidney biopsies from 28 children and 54 adults with male preponderance (68%). Immunofluorescence microscopy showed dominant or co-dominant staining for C1q in the mesangium and occasional glomerular capillary walls. Electron-dense deposits were observed in 48 of 53 cases. Light microscopy revealed no lesions (n = 27), focal segmental glomerulosclerosis (FSGS; n = 11), proliferative glomerulonephritis (n = 20), or various other lesions (n = 14). Clinical presentations in the patients who had no lesions histology were normal urine examination (7%), asymptomatic hematuria and/or proteinuria (22%), and nephrotic syndrome (minimal change-like lesion; 63%), which frequently relapsed. All patients with FSGS presented with nephrotic syndrome. Those with proliferative glomerulonephritis usually presented with chronic kidney disease (75%) or asymptomatic urine abnormalities (20%). Of the patients with sufficient follow-up data, complete remission of the nephrotic syndrome occurred in 77% of tho...Continue Reading

References

Oct 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S S IskandarW B Lorentz
Aug 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J C Jennette, C G Hipp
Apr 1, 1985·American Journal of Clinical Pathology·J C Jennette, C G Hipp
Jun 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S B ShappellA Fogo
May 4, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M NishidaT Sawada
Sep 7, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T SrivastavaU S Alon
Sep 13, 2003·Kidney International·Glen S MarkowitzVivette D D'Agati
Mar 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrew SharmanJohn Feehally
Apr 14, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Keith K LauRobert J Wyatt
Sep 1, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Masashi NishidaKenji Hamaoka
Oct 26, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tanja Kersnik LevartAlenka Vizjak
Feb 24, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yuko FukumaHiroshi Iwasaki
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Laura BarisoniJeffrey B Kopp

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Citations

Aug 12, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Luke TaggartFranca Iorember
Feb 25, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Scott E WenderferMichael C Braun
Jul 16, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mateja Vintar SpreitzerTanja Kersnik Levart
May 18, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Samar M SaidSamih H Nasr
Aug 4, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Damien BrackmanDiana Karpman
Jan 25, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Barbara RuggieroFrancesco Emma
Jul 21, 2010·Journal of Paediatrics and Child Health·Agnieshka JudkinsFrank Willis
Nov 28, 2013·Nephro-urology Monthly·Pavan Malleshappa, Mahesha Vankalakunti
Dec 12, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vindya N GunasekaraKjell Tullus
Oct 23, 2012·Indian Journal of Nephrology·S N MandalG Swarnalata
Oct 13, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ines L'ErarioAlessandra Gianviti
Nov 6, 2012·Annual Review of Medicine·Anuja JavaJane Salmon
Nov 26, 2010·Clinical and Experimental Nephrology·Aditi SinhaStanley C Jordan
Jul 24, 2012·Clinical and Experimental Nephrology·Takashi TakeiKosaku Nitta
Apr 26, 2013·Kidney International·Takehiko Wada, Masaomi Nangaku
Mar 12, 2015·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·K V KanodiaH L Trivedi
Jul 26, 2011·Seizure : the Journal of the British Epilepsy Association·João ChavesJosé L Lima
Feb 29, 2016·Lancet·Jürgen Floege, Kerstin Amann
May 31, 2016·The Korean Journal of Internal Medicine·Jee Wan WeeHyunjin Noh
Dec 8, 2015·Analytical Cellular Pathology (Amsterdam)·Joe DevasahayamUnni Pillai
Mar 25, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emilie C RijninkIngeborg M Bajema
Feb 21, 2018·Arkhiv patologii·V A VarshavskyE I Gudkova
Jan 18, 2019·The Tohoku Journal of Experimental Medicine·Yasushi Chiba, Chiyoko N Inoue
Sep 25, 2010·Renal Failure·Yao-Ko Wen, Mei-Ling Chen
Jun 14, 2017·Canadian Journal of Kidney Health and Disease·Sulaiman AlsaidiSusan Samuel
Dec 1, 2011·NDT Plus·Consolación Rosado RubioJosé Luis Lerma Márquez
Aug 1, 2009·NDT Plus·Mordi MuorahPatrick J O'Donnell
Jan 1, 2020·KI Reports·Cinthia B DrachenbergMario F Rubin
Aug 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·L Leonie van LeeuwenHenri G D Leuvenink

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