Pathology of astrovirus associated diarrhoea in a paediatric bone marrow transplant recipient

Journal of Clinical Pathology
N J SebireW D Cubitt

Abstract

Human astrovirus infection often causes outbreaks of self limiting diarrhoea, but may also infect patients who are immunodeficient or immunocompromised. Although there are previous publications relating to various aspects of astroviruses, there is a minimal amount of literature on the histopathological features of gastrointestinal astrovirus infection in humans. We report the histopathological findings, including immunohistochemical and electron microscopic features, of astrovirus infection in a bone marrow transplant recipient aged 4 years with diarrhoea. The appearance of a small intestinal biopsy did not suggest graft versus host disease, but demonstrated villous blunting, irregularity of surface epithelial cells, and an increase in lamina propria inflammatory cell density. Immunohistochemical staining with a murine astrovirus group specific monoclonal antibody demonstrated progressively more extensive staining in the duodenal and jejunal biopsies, predominantly restricted to the luminal surface and cytoplasm of surface epithelial cells, most marked at the villus tips. Electron microscopic examination demonstrated viral particles within the cytoplasm of enterocytes, focally forming paracrystalline arrays.

References

Jun 7, 1975·Lancet·H Appleton, P G Higgins
Mar 1, 1991·Archives of Disease in Childhood·I R SandersonJ A Walker-Smith
Feb 1, 1990·The Journal of Infectious Diseases·J E HerrmannN R Blacklow
Jul 1, 1980·The Journal of General Virology·E W GrayD R Snodgrass
Jul 1, 1993·The New England Journal of Medicine·G S GrohmannR T Bryan
Nov 21, 2002·The Pediatric Infectious Disease Journal·Douglas K Mitchell
Oct 15, 2003·Journal of Virology·Matthew D KociStacey Schultz-Cherry

❮ Previous
Next ❯

Citations

Apr 2, 2005·Viral Immunology·Matthew D Koci
Apr 2, 2005·Viral Immunology·Lindsey A Moser, Stacey Schultz-Cherry
Aug 19, 2007·Journal of Virology·Lindsey A MoserStacey Schultz-Cherry
Sep 10, 2014·Histopathology·Newton A C S Wong
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marcie TomblynUNKNOWN Centers for Disease Control and Prevention
Feb 14, 2015·Clinics in Perinatology·Sarah A CogginsJörn-Hendrik Weitkamp
Oct 4, 2014·Clinical Microbiology Reviews·Albert BoschSusana Guix
Aug 15, 2015·PloS One·Maria da Penha Trindade Pinheiro XavierEduardo de Mello Volotão
Jul 20, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Diem-Lan VuLaurent Kaiser
Jan 4, 2017·Viruses·Shauna A Marvin
Nov 1, 2016·Experimental Biology and Medicine·Hadi Abou-El-Hassan, Hassan Zaraket
Jun 22, 2010·Revista Da Sociedade Brasileira De Medicina Tropical·Rui Gilberto FerreiraDivina das Dôres de Paula Cardoso
Jan 21, 2017·Viruses·Carlos F Arias, Rebecca M DuBois
Dec 18, 2013·Journal of Virology·Ernesto MéndezSusana López
Feb 18, 2011·Gut Microbes·Kim Hodges, Ravinder Gill
Aug 10, 2019·PeerJ·Ronja V KauerTorsten Seuberlich
May 1, 2020·Nature Communications·Valerie CortezStacey Schultz-Cherry
Sep 25, 2020·Journal of Virology·Dan RenJianqiang Ye
Mar 7, 2021·Viruses·Virginia HargestStacey Schultz-Cherry
Jun 3, 2021·Viruses·Somya AggarwalMegan T Baldridge
Jul 27, 2021·Molecular Systems Biology·Sergio TrianaTheodore Alexandrov
Apr 9, 2021·Experimental Animals·Hanako MoritaNobuhito Hayashimoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

The Pediatric Infectious Disease Journal
Soyhan BagciAndreas Mueller
Proceedings of the National Academy of Sciences of the United States of America
Tobias AllanderBjörn Andersson
© 2021 Meta ULC. All rights reserved