PMID: 8655682Feb 1, 1996Paper

Pathology of deaths associated with "ecstasy" and "eve" misuse

Journal of Clinical Pathology
C M MilroyA R Forrest


To study the postmortem pathology associated with ring substituted amphetamine (amphetamine derivatives) misuse. The postmortem findings in deaths associated with the ring substituted amphetamines 3,4-methylenedioxymethyl-amphetamine (MDMA, ecstasy) and 3,4-methylenedioxyethylamphetamine (MDEA, eve) were studied in seven young white men aged between 20 and 25 years. Striking changes were identified in the liver, which varied from foci of individual cell necrosis to centrilobular necrosis. In one case there was massive hepatic necrosis. Changes consistent with catecholamine induced myocardial damage were seen in five cases. In the brain perivascular haemorrhagic and hypoxic changes were identified in four cases. Overall, the changes in four cases were the same as those reported in heart stroke, although only two cases had a documented history of hyperthermia. Of these four cases, all had changes in their liver, three had changes in their brains, and three in their heart. Of the other three cases, one man died of fulminant liver failure, one of water intoxication and one probably from a cardiac arrhythmia associated with myocardial fibrosis. These data suggest that there is more than one mechanism of damage in ring substituted am...Continue Reading


Mar 14, 1992·Lancet·G R ScreatonS L Cohen
Aug 1, 1992·Lancet·J D Woods, J A Henry
Jul 4, 1992·BMJ : British Medical Journal·I H FahalG M Bell
Jul 4, 1992·BMJ : British Medical Journal·J A Henry
Aug 1, 1992·BMJ : British Medical Journal·D RittooD Rittoo
Aug 1, 1992·BMJ : British Medical Journal·R De Silva, D P Harries
Oct 1, 1992·Scottish Medical Journal·D P Harries, R De Silva
Mar 27, 1987·JAMA : the Journal of the American Medical Association·G P DowlingR O Bost
Aug 14, 1987·JAMA : the Journal of the American Medical Association·C Brown, J Osterloh
Dec 1, 1988·The American Journal of Forensic Medicine and Pathology·R V Suarez, R Riemersma
Jun 1, 1972·Human Pathology·L BianchiM Zimmerli-Ning
Apr 20, 1967·The New England Journal of Medicine·A W Meikle, J R Graybill
Aug 1, 1970·The American Journal of Medicine·M KewG Kent
Aug 1, 1983·Liver·L R Rubel, K G Ishak
Jan 1, 1981·Pathology·T C ChaoJ E Pakiam
Oct 1, 1994·British Journal of Haematology·J C MarshE C Gordon-Smith
Nov 27, 1993·BMJ : British Medical Journal·D L MaxwellJ A Henry
Nov 1, 1993·Postgraduate Medical Journal·S Manchanda, M J Connolly
Dec 1, 1993·Archives of Emergency Medicine·J C HughesR J Evans
Feb 5, 1994·BMJ : British Medical Journal·B Kessel
Jan 1, 1994·Forensic Science International : Synergy·A R ForrestJ C Clark
Sep 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·P M Rothwell, R Grant
Sep 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·J A GledhillJ A Henry


Dec 17, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Edward M MillsJon E Sprague
Mar 7, 2012·Archives of Toxicology·Márcia CarvalhoMaria Lourdes Bastos
Sep 25, 2012·Archives of Toxicology·Diana Dias da SilvaElisabete Silva
Sep 8, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Michael MöllerJörg Neuzner
Apr 1, 2009·Cardiovascular Toxicology·Sylvia K ShenoudaPamela A Lucchesi
Jan 26, 2011·Forensic Science, Medicine, and Pathology·C M Milroy
Apr 18, 2009·Molecular Neurobiology·João Paulo CapelaFélix Carvalho
Sep 9, 2000·Physiology & Behavior·P A O'CainKurt J Varner
Feb 15, 2000·Pharmacology, Biochemistry, and Behavior·M BarrionuevoB Lasheras
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Jon C Cole, Harry R Sumnall
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·K M HegadorenM Bourin
Apr 2, 2003·Pharmacology & Therapeutics·Jon C Cole, Harry R Sumnall
Oct 9, 1998·Journal of Hepatology·V AndreuJ Rodés
Jul 4, 2002·Drug and Alcohol Dependence·Adam R WinstockJohn Ramsey
Oct 27, 1997·Forensic Science International : Synergy·M RotheJ Kunkel
Apr 29, 1998·Forensic Science International : Synergy·W Weinmann, M Bohnert
Jul 22, 1998·Forensic Science International : Synergy·T KellerH Tsuchihashi
Oct 26, 1999·Forensic Science International : Synergy·V FineschiE Turillazzi
Aug 24, 2000·European Psychiatry : the Journal of the Association of European Psychiatrists·C BurgessM Gill
Nov 1, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Gabriel Yin Foo LeeBrian Patrick Brophy
Jan 5, 2002·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Jared StroteHenry Wechsler
Jul 28, 2004·Journal of Clinical Forensic Medicine·John H Galloway, Alexander R W Forrest
Aug 24, 2002·Pharmacology & Toxicology·Marco GesiAntonio Paparelli
Nov 6, 2003·Experimental and Clinical Psychopharmacology·Sean LarawayAlan Poling
Nov 29, 2001·British Journal of Pharmacology·D M CannonG J McBean
Apr 2, 1999·Alimentary Pharmacology & Therapeutics·A L Jones, K J Simpson
Jul 9, 2002·British Journal of Clinical Pharmacology·T C Gilhooly, A K Daly
Apr 15, 2003·Journal of Psychoactive Drugs·Franz X VollenweiderMark Geyer
Feb 4, 2003·Journal of Psychoactive Drugs·Nayyer Iqbal
Sep 17, 2004·Journal of Psychoactive Drugs·Nayyer Iqbal
May 23, 2008·Cardiovascular Research·Sylvia K ShenoudaKurt J Varner
May 15, 2002·The American Journal of Nursing·Valerie Diaz, Mary Mason Wyckoff
May 18, 2000·Heart·A Ghuran, J Nolan

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.