Pathology of explanted cryopreserved allograft heart valves: comparison with aortic valves from orthotopic heart transplants

The Journal of Thoracic and Cardiovascular Surgery
R N MitchellF J Schoen

Abstract

We sought to determine the morphology, mechanisms of deterioration, cellular viability, extracellular matrix integrity, and the role of immune responses in the dysfunction of cryopreserved aortic and pulmonic valve allografts. We studied 33 explanted left-sided (n = 20) or right-sided (n = 13) cryopreserved human allograft heart valves explanted several hours to 9 years after operation, 14 nonimplanted allografts, and 16 aortic valves removed from transplanted allograft hearts 2 days to 4 years after operation. Analysis included gross inspection, radiography, light microscopy, electron microscopy, and immunohistochemical studies. Allografts implanted for more than 1 day had progressive collagen hyalinization and loss of normal structural complexity and cellularity, including endothelium and deep connective tissue cells. Inflammatory cells were generally minimal or absent in the allografts. Transmission electron microscopy of long-term cryopreserved allograft valves revealed no viable cells, focal calcification centered around dead cell remnants, and distorted but preserved collagen. In contrast, aortic valves from transplanted hearts showed remarkable structural preservation, including endothelium and abundant deep connective t...Continue Reading

References

Jan 1, 1977·Cardiovascular Research·D J Wheatley, C G McGregor
Apr 1, 1990·The Annals of Thoracic Surgery·I C TunaG K Danielson
Nov 1, 1989·Cardiovascular Research·J F HuL Wolfinbarger
Aug 1, 1988·The Annals of Thoracic Surgery·O MatsukiD N Ross
May 1, 1974·The Australian and New Zealand Journal of Surgery·M R GirinathB G Barratt-Boyes
Aug 1, 1995·The Annals of Thoracic Surgery·R N MitchellF J Schoen
Aug 1, 1995·The Annals of Thoracic Surgery·L C Armiger
Aug 1, 1995·The Annals of Thoracic Surgery·T FischleinB Reichart
Aug 1, 1995·The Annals of Thoracic Surgery·J D SmithM H Yacoub
Aug 1, 1995·The Annals of Thoracic Surgery·M ValenteG Thiene
Aug 1, 1995·The Annals of Thoracic Surgery·O M ShapiraR J Shemin
Nov 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·P HoganM F O'Brien
Sep 8, 1962·Lancet·D N ROSS
Jan 1, 1997·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Y A GoffinE Gruys

❮ Previous
Next ❯

Citations

Oct 21, 2006·Annals of Biomedical Engineering·Karen Mendelson, Frederick J Schoen
Mar 31, 2011·General Thoracic and Cardiovascular Surgery·Eiki FujimotoTetsuya Kitagawa
Dec 15, 2005·Heart, Lung & Circulation·Cheng-Hon Yap, Michael Yii
Nov 18, 2000·The Annals of Thoracic Surgery·J F LegareD B Ross
Mar 10, 2001·The Annals of Thoracic Surgery·M R BielefeldD R Clarke
Jun 5, 2001·The Annals of Thoracic Surgery·A KadnerD H Adams
Jun 28, 2001·The Annals of Thoracic Surgery·J F BechtelH H Sievers
Aug 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Winfield WellsMark L Barr
Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·Patrick G Hogan, Mark F O'Brien
Apr 16, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S ChauvaudA Carpentier
Aug 7, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ryoichi NakanishiKosei Yasumoto
May 29, 2002·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Ruma RayA Sampath Kumar
Dec 3, 2002·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Elena Rabkin, Frederick J Schoen
Apr 30, 2003·Transplantation·Kelvin G M Brockbank, Ying C Song
Apr 29, 2006·Artificial Organs·Luca DaineseGianluca Polvani
Oct 31, 2008·Artificial Organs·Kiick SungJung Wook Seo
Mar 17, 2005·The Heart Surgery Forum·P M DohmenW Konertz
Dec 10, 1999·The Annals of Thoracic Surgery·A OsmanH L Lazar
Sep 29, 2011·Annual Review of Pathology·Frederick J Schoen
Jun 1, 2012·Surgical Pathology Clinics·Paul A VanderLaanFredrick J Schoen
Oct 1, 2011·The Annals of Thoracic Surgery·Pascal M DohmenWolfgang Konertz
Jan 5, 2016·The Journal of Thoracic and Cardiovascular Surgery·Viola SteffenOmke E Teebken
Oct 24, 2007·Biomaterials·Peter ZillaDeon Bezuidenhout
Feb 27, 2007·The Journal of Thoracic and Cardiovascular Surgery·Matthew A HarrisMark A Fogel
Sep 1, 2005·Clinics in Laboratory Medicine·Manish J Gandhi, D Michael Strong
Oct 1, 2004·The Journal of Thoracic and Cardiovascular Surgery·Elena Rabkin-AikawaFrederick J Schoen
Oct 29, 2002·The Annals of Thoracic Surgery·Robert E Shaddy, John A Hawkins
Apr 26, 2001·American Heart Journal·L H Edmunds
Sep 10, 1998·The Journal of Thoracic and Cardiovascular Surgery·M KawauchiS Takamoto
Jan 29, 2000·The Journal of Thoracic and Cardiovascular Surgery·J A HawkinsR E Shaddy
Apr 28, 2005·The Annals of Thoracic Surgery·Friedhelm SaykHans-H Sievers
Mar 23, 2005·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Shigeo NagasakaHiroyuki Morioka
Aug 2, 2000·The Annals of Thoracic Surgery·R SodianJ E Mayer
Sep 25, 2015·Expert Reviews in Molecular Medicine·Andres Sanz-GarciaCarmen Escobedo-Lucea
Feb 14, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Alejandro TorresDoff B McElhinney
Jun 1, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Frederick J Schoen, Avrum I Gotlieb
Jun 12, 2016·The Journal of Thoracic and Cardiovascular Surgery·J F Matthias Bechtel
Mar 20, 2010·The Journal of Thoracic and Cardiovascular Surgery·Bryce J LaingIvan M Rebeyka
Aug 30, 2000·The Journal of Thoracic and Cardiovascular Surgery·A S KumarP Chopra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cellular Immunometabolism

Immunometabolism involves not only the way metabolites are digested by the immune system, but the way in which they can alter the pathway of the immune system. These responses occur in day-to-day healthy cell functioning, but can result in diseases, such as autoimmune disorders. Discover the latest research on cellular immunometabolism here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

The Journal of Thoracic and Cardiovascular Surgery
B RajaniN B Ratliff
The Journal of Thoracic and Cardiovascular Surgery
M KawauchiS Takamoto
The Journal of Thoracic and Cardiovascular Surgery
Patrick G HoganM F O'Brien
© 2021 Meta ULC. All rights reserved