Pathology of human intestinal transplantation

Gastroenterology
R G LeeA J Demetris

Abstract

Intestinal transplantation is a developing therapeutic option for patients with irreversible intestinal failure or short bowel syndrome. The aim of this study was to delineate the histopathology of human intestinal allografts and to define the features of intestinal rejection. The histological features of 3015 endoscopic biopsy specimens and 23 allograft specimens from 62 intestinal recipients were analyzed retrospectively and correlated with clinical findings. Acute allograft rejection was characterized by a varying combination of crypt injury, mucosal infiltration primarily by mononuclear cells (including blastic lymphocytes), and increased crypt cell apoptosis (more than 2 per 10 crypts). It represented a patchy, often ileal-centered process that could progress to mucosal ulceration; later episodes (more than 100 days posttransplant) tended to show lesser cellular infiltration and greater apoptosis than earlier episodes. Correlation with clinical rejection was good (false-positive rate of 9%; false-negative rate of 26%). Two resected specimens showed obliterative arteriopathy indicative of chronic rejection. In other specimens, preservation injury, cytomegalovirus infection, post-transplant lymphoproliferative disorder, and ...Continue Reading

Citations

Jul 2, 1999·Pediatric Transplantation·O Goulet
Sep 12, 2000·Current Gastroenterology Reports·L SigurdssonS A Kocoshis
May 25, 2001·Current Opinion in Critical Care·A Ghanekar, D Grant
Dec 21, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Phillip RuizAndreas Tzakis
Jul 17, 2003·Transplantation·Rebecca J PinchoffBetsy C Herold
Mar 25, 2005·Pediatric Transplantation·Camila MacedoJorge Reyes
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Rebecca A Weseman, Richard Gilroy
Jan 21, 2006·World Journal of Gastroenterology : WJG·Stelios F AssimakopoulosConstantine E Vagianos
Nov 27, 2010·Surgery Today·Takehisa Ueno, Masahiro Fukuzawa
May 12, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Tadafumi AsaokaPhillip Ruiz
Jun 27, 2012·Journal of Intensive Care Medicine·Reinhard HopfnerGwenn E McLaughlin
Jul 27, 2012·International Journal of Surgical Pathology·Geoffrey TalmonJames Wisecarver
Jan 24, 2015·Current Gastroenterology Reports·Chandrashekhar A KubalA Joseph Tector
Oct 6, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C E KovalK Abu-Elmagd
Jan 24, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ahmed M ElsabbaghCal S Matsumoto
Oct 22, 2019·Inflammatory Bowel Diseases·Hamma FahadClaudio Fiocchi
Jul 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·O GouletC Ricour
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·O Goulet
Sep 14, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·O GouletY Révillon
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stuart S KaufmanThomas M Fishbein
Sep 5, 2002·The Journal of Pathology·Neena KaliaA Graham Pockley
Mar 21, 1998·The American Journal of Surgical Pathology·L FinnE Yunis
Jan 30, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Shin-ichi Noguchi SiRonald Jaffe
May 13, 2003·Scandinavian Journal of Gastroenterology·S FujisakiK Matsumoto
Dec 12, 2001·Pediatric Transplantation·J PirenneR Van Damme-Lombaerts
Apr 30, 2003·Transplantation·Tong WuA Jake Demetris
Jan 11, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·O GouletC Ricour
Mar 27, 2003·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Maria ParizhskayaKareem Abu-Elmagd
Mar 18, 2006·Surgical Endoscopy·T KatoA G Tzakis
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zheng ZhangJonathan Fryer
Jul 19, 2002·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Beverly Kosmach Park
Jan 16, 2007·Transplantation·Phillip RuizAndreas Tzakis
Mar 24, 2007·Digestive Diseases and Sciences·Mark DeLeggeNicole M Moore
Dec 6, 2008·The American Journal of Clinical Nutrition·Laura E MatareseKareem M Abu-Elmagd
May 25, 2010·Surgery Today·Norio YoshimuraMasahiko Okamoto
May 9, 2014·Current Opinion in Organ Transplantation·Phillip Ruiz
Mar 3, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Tatsuaki TsuruyamaHironori Haga
Jul 5, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R GirlandaT M Fishbein

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