PMID: 41111Jul 1, 1979

Pathology of Kawasaki disease: I. Pathology and morphogenesis of the vascular changes

Japanese Circulation Journal
S AmanoY Hamashima

Abstract

Histopathological investigation of the vascular changes in Kawasaki disease was carried out on thirty-seven autopsied Japanese patients. Arterial lesions could be classified into following five stages from the view point of morphogenesis of arteritis; 1) endothelial degeneration and increased vascular permeability, 2) edema and degeneration of the media, 3) necrotizing panarteritis, 4) granulation formation, and 5) scarformation. Aneurysm with thrombus was observed mainly in the coronary artery in most patients. It is considered that the initial changes begins in the endothelial cells with increased vascular permeability. Platelet aggregation in the damaged endothelial cells seems to play an important role in the further development of the arteritic changes. Vascular lesions were observed not only in the arterial system but also in the venous system, therefore Kawasaki disease is a systemic vasculitis rather than a systemic arteritis.

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Related Concepts

Muscle, Smooth, Vascular
Vasculitis
Mucocutaneous Lymph Node Syndrome
Arterial System
Status Lymphaticus
Abnormal Degeneration
Platelet Aggregation Measurement
Bulla
Blood Vessel
Aneurysm

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