Pathology of liver metastases

Cancer Control : Journal of the Moffitt Cancer Center
Barbara A Centeno

Abstract

The liver is the most frequent site of metastatic disease, and metastatic disease to the liver is far more common than primary liver carcinoma in the United States. Pathologic evaluation of biopsy samples is key to establishing a correct diagnosis for patient management. Morphologic and immunoperoxidase studies, which are the standard for pathologic practice, accurately classify most tumors. Subclassification of carcinoma of unknown primary remains problematic. The author reviewed the literature for articles pertaining to liver biopsy, diagnosis of specific tumor types, utility of immunohistochemical markers, and microarray and proteomic analysis. Sampling of liver lesions is best accomplished by combining fine-needle aspiration and needle core biopsy. Many malignancies have distinct morphologic and immunohistochemical patterns and can be correctly subclassified. Adenocarcinoma of unknown primary remains enigmatic since current immunohistochemical markers for this differential diagnosis lack specificity. Microarray analysis and proteomic analysis of tumors can provide distinct gene or protein expression profiles, respectively, for tumor classification. These technologies can be used with fine-needle aspiration and needle core b...Continue Reading

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Citations

Apr 20, 2013·Oncology Letters·Suchanan Hanamornroongruang, Napakorn Sangchay
Aug 10, 2013·Cancer Medicine·Shuko HataHironobu Sasano
Feb 7, 2013·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ágnes HolczbauerAndrás Kiss

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