Pathology of lung allografts in children and young adults

Human Pathology
K Badizadegan, A R Perez-Atayde

Abstract

Heart-lung and lung transplantation have become acceptable therapeutic modalities for end-stage lung and heart conditions in children and young adults, but the posttransplantation pulmonary pathology in this age-group is poorly characterized. We present our experience with the pathology of lung transplantation in a cohort of 11 patients with a median age of 12.5 years, and median posttransplantation follow-up of 8.3 months. The findings are based on histological examination of 98 specimens, including five autopsy specimens from patients 20 years of age or younger. Our experience, combined with the data in other pediatric series, suggest that there is not a significant difference in the prevalence or severity of acute rejection or bronchiolitis obliterans (BO) between adult and pediatric lung transplant recipients. Lymphocytic bronchitis/bronchiolitis showed a more prominent association with BO in our series than previously reported in adult studies. Chronic vascular rejection in the pediatric lung transplant recipients can occur earlier than reported in adults and is associated with a grave prognosis. Overwhelming infection was a major cause of death in our experience. In particular, our data combined with the previous reports ...Continue Reading

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Citations

Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·A De SoyzaP A Corris
Jan 8, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alin L GirnitaAdriana Zeevi
Jan 31, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Megan K DishopFrances V White
Apr 20, 2004·Pediatric Pulmonology·Athanasios G KaditisMarian G Michaels

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