PMID: 22583433May 16, 2012Paper

Pathology of multiple sclerosis

CNS & Neurological Disorders Drug Targets
Markus KippSandra Amor

Abstract

Pathological examination of the affected human tissue is key to understanding the possible mechanisms operating in the disease. In multiple sclerosis (MS), studies of central nervous system (CNS) tissues reveal the inflammatory nature of the disease associated with demyelination and axonal damage. Based on the concept of a pathogenic adaptive immune response, immunosuppressive therapies have been developed in an attempt to block or inhibit the potentially pathogenic T and B cells. More recently, re-examination of the neuropathology has led to a resurgence of interest in the neurodegenerative aspects of the disease, the involvement of cortical damage as well as the role of innate immunity in MS. These ideas have led to paradigm shifts from MS being the result of autoimmunity to myelin due to initial adaptive immune responses, to that of a neurodegenerative disease in which, besides T and B cells, innate immunity may play a major role in the disease process. The neuropathological studies have undoubtedly influenced pharmaceutical interest in development of neuroprotective approaches. Here we review the latest findings from pathological studies of MS tissues and discuss the relevance of these findings for future therapeutic approa...Continue Reading

Citations

Oct 16, 2013·Journal of Neuroinflammation·Ganta Vijay ChaitanyaJonathan S Alexander
Sep 25, 2014·Dose-response : a Publication of International Hormesis Society·Noriko Shimura, Shuji Kojima
Jun 13, 2015·Journal of Molecular Neuroscience : MN·Johannes GoldbergMarkus Kipp
Dec 31, 2017·Molecular Neurobiology·Stefan EsserLars-Ove Brandenburg
Apr 15, 2014·BioMed Research International·Lorenzo Di Cesare MannelliCarla Ghelardini
Sep 14, 2015·Molecular Neurobiology·René Große-VeldmannMarkus Kipp
Jun 20, 2015·Cell Adhesion & Migration·Xupin JiangYuesheng Huang
Aug 31, 2018·Journal of Immunology Research·Margarete Dulce BagatiniFabiano Barbosa Carvalho
Aug 10, 2019·Frontiers in Immunology·Melissa SchepersTim Vanmierlo
May 4, 2017·Journal of Molecular Neuroscience : MN·Kai BihlerLars-Ove Brandenburg
Nov 25, 2014·Cellular and Molecular Life Sciences : CMLS·Markus KippOmid Nikoubashman
Apr 29, 2015·International Journal of Molecular Sciences·Juan XiaoWenbin Deng
Nov 9, 2016·Journal of Molecular Neuroscience : MN·Markus KippChristoph Schmitz
Jun 2, 2016·Journal of Immunoassay & Immunochemistry·Shamsi NaderiNahid Sedaghat
Aug 6, 2016·Journal of Molecular Neuroscience : MN·Nina WagenknechtMarkus Kipp

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