Pathology of spontaneous and experimental infections by Goose haemorrhagic polyomavirus

Avian Pathology : Journal of the W.V.P.A
Caroline LacrouxJean-Luc Guerin

Abstract

Haemorrhagic nephritis enteritis of geese (HNEG) is a fatal disease of geese aged from 3 to 12 weeks. The causative virus, Goose haemorrhagic polyomavirus (GHPV), is a member of the Polyomaviridae family We examined goslings either spontaneously or experimentally infected with GHPV. Tissues were sampled for histology, GHPV DNA detection and electron microscopy. Clinical signs and gross lesions observed in experimentally infected goslings were largely consistent with those noticed in field cases. Histological examination showed that, in the acute phase of HNEG, GHPV replicates in almost all the tissues with a particular tropism for endothelial and lymphoid cells. Haemorrhagic foci were widespread in many tissues, including brain. Ultrastructural features were largely consistent with other polyomavirus infections, with accumulation of virions in the nucleus. Non-typical, double-membraned organelles were observed in the cytoplasm. GHPV DNA distribution was widespread in tissues of infected birds, from day 5 post-infection. GHPV therefore induces a systemic disease in its host, leading to severe vascular dysfunction and immunosuppressive B-cell depletion.

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Citations

Mar 16, 2006·Avian Pathology : Journal of the W.V.P.A·Dave Cavanagh
Feb 2, 2006·Avian Pathology : Journal of the W.V.P.A·Sándor BernáthMihály Dobos-Kovács
Apr 15, 2010·Avian Pathology : Journal of the W.V.P.A·Jacqueline GelfiJean-Luc Guerin
Aug 5, 2011·Avian Pathology : Journal of the W.V.P.A·Léni CorrandJean-Luc Guerin
Aug 24, 2007·Journal of Virology·Reimar Johne, Hermann Müller
Mar 7, 2014·Avian Diseases·Olivier LeonJean-Luc Guérin
May 12, 2015·Avian Pathology : Journal of the W.V.P.A·Grzegorz Woźniakowski, Karolina Tarasiuk
Jun 19, 2014·Acta Microbiologica Et Immunologica Hungarica·Enikő FehérKrisztián Bányai
May 2, 2008·International Journal of Cancer. Journal International Du Cancer·Harald Zur Hausen
Aug 19, 2007·Animal Health Research Reviews·E Behling-Kelly, C J Czuprynski
May 7, 2020·Transboundary and Emerging Diseases·Eszter KaszabEnikő Fehér
Oct 12, 2018·Journal of Veterinary Science·Chunhe WanYu Huang
Jul 8, 2018·Archives of Virology·Meiling JinDabing Zhang
Feb 5, 2008·The Veterinary Record·J-L PingretJ-L Guérin
Oct 7, 2020·Avian Pathology : Journal of the W.V.P.A·Yang-Chang TuYen-Ping Chen
Sep 22, 2021·Avian Pathology : Journal of the W.V.P.A·Eszter KaszabEnikő Fehér

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Methods Mentioned

BETA
PCR
electrophoresis
electron microscopy

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