PMID: 45919Jan 1, 1975Paper

Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome)

Human Pathology
W CreutzfeldtN S Track


The clinical symptomatology of the Zollinger-Ellison syndrome and the pathologic anatomy of gastrinomas are reviewed. Experience with 17 patients with the Zollinger-Ellison syndrome is presented with special reference to stimulation tests (secretin, glucagon, calcium infusion, test meal) and to localization and immunohistologic, ultrastructural, and biochemical findings in gastrinomas. Multiple hormone production by the tumors is frequent. The ultrastructure and the Sephadex G-50 gel filtration patterns of immunoreactive gastrin in sera and tumors are not uniform and are not related to localization of the tumors in the pancreas or duodenum or to the gastrin concentration. Hyperplasia of the pancreatic islets is a frequent finding in gastrinoma patients, suggesting that hypergastrinemia may stimulate islet growth.


Sep 20, 1979·World Journal of Surgery·W Creutzfeldt, R Arnold
Apr 22, 1976·The New England Journal of Medicine·P M LeCompter
Nov 1, 1978·The American Journal of Digestive Diseases·C B LamersJ F Rehfeld
Jul 15, 1987·Experientia·E SolciaE Silini
Jun 12, 1980·The New England Journal of Medicine·D M McCarthy
Dec 4, 2003·Drugs & Aging·Paola TomassettiRoberto Corinaldesi
Aug 24, 2006·Annals of Surgery·Jeffrey A NortonRobert T Jensen
Aug 27, 2016·European Journal of Endocrinology·Thomas G K BreuerJ J Meier
Oct 1, 1990·European Journal of Clinical Investigation·E SolciaC Capella
Dec 1, 1990·Scandinavian Journal of Gastroenterology·L Bardram
Jan 1, 1985·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T Bani SacchiG Biliotti
Mar 1, 1980·Veterinary Pathology·R P HappéL I Larsson
Dec 16, 1982·The New England Journal of Medicine·W Silen
Jul 1, 1983·Scandinavian Journal of Gastroenterology·B Petersen, B N Andersen
Sep 1, 1980·Cancer·T F WarnerA G Pearse
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·E Wilander
Feb 1, 1981·The British Journal of Surgery·N BassoV Speranza
Aug 6, 2008·Pediatric Surgery International·Subramanya KattepuraHarshad Devarabhavi
Mar 1, 1990·Endocrine Pathology·A E Bishop, J M Polak
Sep 1, 1990·Scandinavian Journal of Gastroenterology·L Bardram
Mar 15, 1990·The New England Journal of Medicine·M Pipeleers-MarichalP U Heitz
Nov 25, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·L I Larsson
Mar 1, 1983·Acta Pathologica Japonica·T Kodama
Apr 28, 1977·The New England Journal of Medicine·O P GandaS Reichlin
Jul 3, 1986·The New England Journal of Medicine·P N MatonR T Jensen
Mar 1, 1982·Klinische Wochenschrift·D Grube
Nov 5, 1987·The New England Journal of Medicine·M M Wolfe, R T Jensen
May 1, 1996·Journal of Computer Assisted Tomography·J F BergerE Schouman-Claeys
Jul 1, 1981·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·E Wilander, M El-Salhy
Sep 30, 2000·Alimentary Pharmacology & Therapeutics·A M Smith, S A Watson

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