Pathomorphological features of acute rejection in patients after orthotopic liver transplantation: own experience

Transplantation Proceedings
B GórnickaA Wasiutyński

Abstract

Acute hepatic allograft rejection remains an important problem following liver transplantation. Liver biopsy specimens show a combination of characteristic changes, first observed by Snover as a diagnostic triad: portal inflammation, bile duct damage, and central or portal vein endothelial inflammation (endothelitis or endothelialitis). The aim of this study was to describe our histopathological assessment of liver transplants. In the period between September 2000 and June 2004, we evaluated 150 liver biopsy specimens from 105 liver recipients. Acute rejection was diagnosed in 26.6% of liver biopsies taken from 31.4% patients who demonstrated clinical symptoms of liver damage. In 90% of cases the rejection was described as minimal or mild, and in 10% as moderate. There was no episode of severe acute rejection. Only four biopsies (10%) showed nothing but Snover triad changes. In 9 (22.5%) cases only acute rejection was diagnosed; the remaining showed in addition to acute rejection the possibility of other concomitant pathologies: viral infection in 15 cases (37.5%), biliary flow obstruction in 11 cases (28.5%), functional cholestasis in two cases (5%), and ischemic complications in three cases (7.5%). Histologically confirmed ac...Continue Reading

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Citations

Sep 14, 2013·Hepatitis Monthly·Bita GeramizadehSeyed Ali Malek Hosseini
Feb 27, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Lihong ChenHanlin L Wang
Jul 25, 2009·Language and Speech·Marion Dohen, Hélène Loevenbruck
Feb 12, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Lihong ChenHanlin L Wang

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