Pathophysiologic and therapeutic implications of adrenomedullin in cardiovascular disorders

Pharmacology & Therapeutics
Toshihiko IshimitsuHiroaki Matsuoka

Abstract

Adrenomedullin (AM) is a vasodilator peptide that originally isolated from pheochromocytoma tissue. However, the mRNA is expressed in the normal adrenal gland, heart, kidney and blood vessels. The human AM gene is located in the short arm of chromosome 11 and is composed of 4 exons. There are 2 single nucleotide polymorphisms in introns 1 and 3, and the 3'-end of the AM gene is flanked by a microsatellite marker of cytosine-adenine repeats that is associated with an increased risk of developing hypertension and diabetic nephropathy. AM gene expression is promoted by various stimuli, including inflammation, hypoxia, oxidative stress, mechanical stress and activation of the renin-angiotensin and sympathetic nervous systems. The AM gene promoter region possessed binding site for several transcription factors, including nuclear factor for interleukin-6 expression (NF-IL6) and activator protein 2 (AP-2). Further, plasma AM levels are increased in patients with various cardiovascular diseases, including hypertension, heart failure and renal failure. These findings suggest that AM plays a role in the development of or response to cardiovascular disease. Indeed, experimental and clinical studies have demonstrated that systemic infusion...Continue Reading

References

Oct 24, 1995·Biochemical and Biophysical Research Communications·E N ChiniT P Dousa
Nov 15, 1995·Journal of the American College of Cardiology·T NishikimiH Matsuoka
Jul 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Sep 15, 1993·Biochemical and Biophysical Research Communications·J SakataT Eto
Nov 30, 1994·Biochemical and Biophysical Research Communications·H KanazawaT Takeda
Aug 30, 1994·Biochemical and Biophysical Research Communications·T IshimitsuH Matsuo
Mar 21, 1994·FEBS Letters·K KitamuraT Eto
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·X WangG Z Feuerstein
Jan 1, 1996·Hypertension·M KohnoJ Yoshikawa
Feb 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·R C VariW K Samson
Apr 1, 1996·The Journal of Clinical Endocrinology and Metabolism·Y HirataF Marumo
Feb 1, 1996·Journal of Hypertension·H KanoJ Yoshikawa
Dec 1, 1995·Journal of Neuroendocrinology·D G Parkes, C N May
Sep 20, 1996·The Journal of Biological Chemistry·M J MillerF Cuttitta
Jun 1, 1996·European Journal of Clinical Investigation·M TaniyamaT Katagiri
Jan 1, 1997·Stroke; a Journal of Cerebral Circulation·M G LangD D Heistad
Jan 13, 1997·Biochemical and Biophysical Research Communications·A SatoD J Autelitano
Feb 1, 1997·Clinical and Experimental Pharmacology & Physiology·A I KhanT Eto
Apr 1, 1997·The Journal of Clinical Endocrinology and Metabolism·P G AndreisG G Nussdorfer
May 1, 1997·Clinical Science·J G LainchburyM G Nicholls
Aug 27, 1997·European Journal of Pharmacology·A I KhanT Eto
Dec 12, 1997·Biochimica Et Biophysica Acta·A Minden, M Karin

❮ Previous
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Citations

Oct 7, 2010·European Journal of Applied Physiology·Andreas RoesslerHelmut Hinghofer-Szalkay
May 23, 2007·Heart Failure Reviews·Dwaine S BurleyGary F Baxter
Aug 12, 2009·Hepatology International·Florence Wong
Aug 13, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takuo HiroseYutaka Imai
Sep 13, 2011·Nature·UNKNOWN International Consortium for Blood Pressure Genome-Wide Association StudiesToby Johnson
Feb 3, 2007·Nature Reviews. Drug Discovery·David M Kaye, Henry Krum
Oct 25, 2011·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Juliana T RochaCarlos R Tirapelli
Sep 2, 2010·Circulation·Daniela TirziuMichael Simons
Dec 22, 2007·The Journal of Clinical Investigation·Kimberly L Fritz-SixKathleen M Caron
Mar 18, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ramón RodrigoJean P Bächler
Dec 14, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Michael BehnesMartina Brueckmann
Jul 30, 2011·European Journal of Endocrinology·Bernard M Y CheungUNKNOWN Investigators of Hong Kong Cardiovascular Risk Factor Prevalence Study
Mar 1, 2012·World Journal of Surgery·James Kirkby-BottBruno Carnaille
Nov 16, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kwok Leung OngKaren S L Lam
Aug 12, 2008·European Journal of Heart Failure·Takuo HiroseYutaka Imai
Oct 24, 2012·Clinical Endocrinology·Hoi Kin WongBernard M Y Cheung
Mar 17, 2010·Pacing and Clinical Electrophysiology : PACE·Maria-Aurora MoralesSilvia Del Ry
May 29, 2015·European Journal of Nutrition·Silvia Del RyGiovanni Federico
Nov 22, 2011·Journal of Molecular and Cellular Cardiology·Cordelia J BarrickKathleen M Caron
Feb 16, 2015·The American Journal of Cardiology·Matthew F YuyunLeong L Ng
Jan 15, 2016·Journal of Cardiovascular Medicine·Matthew F YuyunLeong L Ng
Aug 21, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L N LeiteC R Tirapelli
Jan 1, 2012·JRSM Cardiovascular Disease·Hoi Kin WongBernard M Y Cheung
Sep 28, 2018·Personalized Medicine·Jin DengWeiming Zeng
Jul 20, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nathalie DehneJoachim Fandrey
Aug 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chikako Iemura-InabaHiroaki Matsuoka
Feb 7, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Thor Allan StenbergTruls Myrmel

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