PMID: 9164712May 1, 1997Paper

Pathophysiologic basis for vasodepressor syncope

Cardiology Clinics
Carlos A. MorilloL Fernando Pava

Abstract

The current knowledge regarding the pathophysiologic basis of the vasodepressor response was reviewed. The balance of evidence indicates that the mechanoreceptor hypothesis seems unlikely to be the sole afferent alteration that leads to the vasodepressor response. Alternative afferent mechanisms should include neurohumoral mediated sympathoinhibition triggered by opioid mechanisms as well as impaired endothelial and NO responses to orthostatic stress in susceptible individuals. It is possible that impaired cardiovagal and sympathetic outflow control of arterial baroreceptors is enhanced by the aforementioned mechanisms. The role of central sympathoinhibition and vagal excitation triggered directly from pathways within the temporal lobe or triggered by alterations in regional cerebral blood flow should be considered as potential alternative mechanisms. Efferent autonomic outflow during vasodepressor syncope include sympathetic neural outflow withdrawal in addition to activation of parasympathetic outflow to the heart and abdominal viscera. Further human research is needed to understand the underlying mechanisms that result in the described neural and vascular responses.

References

Aug 1, 1975·Circulation Research·S F VatnerR J McRitchie
Apr 11, 1991·Journal of the American College of Cardiology·J C Perry, A Garson
Mar 1, 1990·The New England Journal of Medicine·U ScherrerR G Victor
Jul 1, 1990·Journal of the American College of Cardiology·G PongiglioneD W Benson
Dec 1, 1989·Journal of the American College of Cardiology·R F Rea
Apr 1, 1988·Clinical Science·B J Robinson, R H Johnson
Jan 1, 1970·Circulation·S OparilE Haber
Aug 1, 1973·Acta Physiologica Scandinavica·H Abrahamsson, P Thorén
Jun 1, 1972·Acta Physiologica Scandinavica·B Oberg, P Thorén
Nov 1, 1970·Acta Physiologica Scandinavica·B Oberg, S White
Apr 1, 1968·Circulation·S E EpsteinG D Beiser
Oct 1, 1965·Journal of Psychosomatic Research·J J Chosy, D T Graham
Mar 1, 1984·Psychosomatic Medicine·A J Vingerhoets
Nov 1, 1982·Journal of the Autonomic Nervous System·B G Wallin, G Sundlöf
Nov 1, 1994·Pacing and Clinical Electrophysiology : PACE·E PruvotL Kappenberger
Oct 1, 1994·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·R Hainsworth, K M el-Bedawi
Jul 1, 1994·The American Journal of Medicine·W N KapoorN L Miller
Oct 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·U PassantL Edvinsson
Dec 1, 1993·The American Journal of Cardiology·J F SneddonM Malik
Oct 1, 1993·Journal of Cardiovascular Electrophysiology·R F Rea, M D Thames
Oct 1, 1995·European Journal of Clinical Investigation·M C JacobsJ W Lenders
May 1, 1996·Heart·D L JardineI G Crozier
Jul 1, 1996·Journal of the American College of Cardiology·D G BendittD L Wood
Jun 1, 1957·Circulation·A M WEISSLERJ J LEONARD
Oct 11, 1958·British Medical Journal·E P SHARPEY-SCHAFERE D BARLOW
Jul 1, 1961·Archives of Neurology·H R KARPA HEYMAN
Jan 1, 1963·The American Journal of Medicine·G GLICK, P N YU
May 1, 1938·The Journal of Clinical Investigation·N E FreemanN E Marean
May 14, 1932·British Medical Journal·T Lewis
Aug 30, 1941·British Medical Journal·R T Grant, E B Reeve

❮ Previous
Next ❯

Citations

Jan 25, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Carlos A MorilloJuan C Guzmán
Aug 25, 2004·Current Treatment Options in Cardiovascular Medicine·Carlos A. Morillo, Adrián Baranchuk
Feb 7, 2004·Archives of Gerontology and Geriatrics·V SimJ Woo
Aug 16, 2002·Heart·M A MercaderS W Lee
Apr 7, 2006·Postgraduate Medical Journal·J E NaschitzI Rosner
Aug 20, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Monish S Raut, Arun Maheshwari
Dec 19, 2006·Taiwanese Journal of Obstetrics & Gynecology·Pei-Shan TsaiMing-Song Tsai
Nov 10, 2004·Journal of Electrocardiology·Markus KhalilHerbert E Ulmer
Aug 4, 2004·Medical Hypotheses·Niko Zurak, Ervina Bilic
Jun 16, 2001·Cardiology Clinics·C S Cadman
Aug 9, 2002·Anesthesiology Clinics of North America·Monica S VavilalaArthur M Lam
Jun 24, 2006·Annales de cardiologie et d'angéiologie·E SalaméR Kassab
Sep 28, 2001·British Journal of Anaesthesia·S M Kinsella, J P Tuckey
Oct 12, 2004·AACN Clinical Issues·Bonnie Sealey, Karen Lui
Jun 2, 2000·Pacing and Clinical Electrophysiology : PACE·T J CohenF von zur Muhlen
Jun 16, 2005·Pacing and Clinical Electrophysiology : PACE·N IlginK Gücüyener
Aug 21, 2008·Anesthesia and Analgesia·Hayden White, Bala Venkatesh
Oct 15, 2008·Journal of Cardiovascular Medicine·Enrico FavarettoClaudio Bilato
Mar 17, 2001·Journal of General Internal Medicine·L A AaronD Buchwald
Apr 22, 2006·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Juan Camilo GuzmanCarlos A Morillo
Jan 20, 2021·JAMA Internal Medicine·Takahiro TsushimaJayakumar Sahadevan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.