Pathophysiologic mechanisms of biomedical nanomaterials

Toxicology and Applied Pharmacology
Liming Wang, Chunying Chen

Abstract

Nanomaterials (NMs) have been widespread used in biomedical fields, daily consuming, and even food industry. It is crucial to understand the safety and biomedical efficacy of NMs. In this review, we summarized the recent progress about the physiological and pathological effects of NMs from several levels: protein-nano interface, NM-subcellular structures, and cell-cell interaction. We focused on the detailed information of nano-bio interaction, especially about protein adsorption, intracellular trafficking, biological barriers, and signaling pathways as well as the associated mechanism mediated by nanomaterials. We also introduced related analytical methods that are meaningful and helpful for biomedical effect studies in the future. We believe that knowledge about pathophysiologic effects of NMs is not only significant for rational design of medical NMs but also helps predict their safety and further improve their applications in the future.

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Citations

Apr 26, 2018·International Journal of Environmental Research and Public Health·Anik KaranMark A DeCoster
Dec 13, 2017·Environmental Science. Nano·Bo WangFeng Ding
Dec 28, 2018·Advanced Materials·Rong Cai, Chunying Chen
Aug 10, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Roel F M R KerstenSteven M van Gaalen

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