Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-Lepr fa (SDT fatty) rats, a novel type 2 diabetic model

The Journal of Veterinary Medical Science
Tatsuya MaekawaShinichi Kume

Abstract

In recent years, a relationship between diabetes and neurodegenerative diseases, such as Parkinson's disease, Alzheimer disease or depression, has been proposed. In this study, pathophysiological changes in the brain, especially in the hippocampus, of male SDT fatty rats with obesity and hyperglycemia were investigated. Brains of SD rats and SDT fatty rats were collected at 32 and 58 weeks of age, and parietal cortical thickness and number of pyramidal cells in the hippocampal cornu ammonis 1 and 3 (CA1 and CA3) regions were measured. At 58 weeks of age, the parietal cortical thickness and number of pyramidal cells in the hippocampal CA1 and CA3 regions were lower in SDT fatty rats than in age-matched SD rats. Measurements of mRNA in rat brains at 58 weeks of age showed that the expression of genes related to inflammatory responses (S100a9, TNFα, NF-κB) was elevated in SDT fatty rats. From the aforementioned results, changes suggestive of brain atrophy and impairment in cognitive function were observed in male SDT fatty rat brains.

References

Oct 1, 1995·Experimental Animals·M TanakaT Kakishita
Aug 28, 1998·Journal of Neural Transmission·L FrölichP Riederer
May 26, 2001·Diabetes Care·R J AndersonP J Lustman
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 26, 2002·Brain Research·Zhen-Guo LiAnders A F Sima
Nov 5, 2003·Diabetologia·T den HeijerM M B Breteler
Dec 8, 2004·Physiology & Behavior·Alexandre BélangerSylvain Gagnon
Oct 29, 2005·Neurobiology of Aging·C E ShepherdG M Halliday
Jan 26, 2007·Diabetes Care·Gang HuJaakko Tuomilehto
Apr 26, 2007·Diabetes·Zhen-guo LiAnders A F Sima
Apr 19, 2008·Experimental Animals·Kenichi MatsuiMutsuyoshi Matsushita
Nov 22, 2008·Biochimica Et Biophysica Acta·Shayna A WrightenLawrence P Reagan
Nov 4, 2009·Journal of Diabetes Science and Technology·Suzanne M de la Monte, Jack R Wands
Dec 19, 2009·The Journal of Biological Chemistry·Minoru MatsudaTohru Mizushima
Mar 13, 2010·Experimental Animals·Yukihito IshiiMutsuyoshi Matsushita
Sep 28, 2010·Journal of the Neurological Sciences·Manon BrundelUNKNOWN Utrecht Diabetic Encephalopathy Study Group
Dec 31, 2011·Stroke; a Journal of Cerebral Circulation·Elizabeth GemmellRaj N Kalaria
Aug 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Kathy F YatesAntonio Convit
May 18, 2013·Neuroscience and Biobehavioral Reviews·Nancy HoIrwin Lucki
Aug 14, 2013·Diabetes Care·Chris MoranVelandai Srikanth
Dec 18, 2013·Autoimmunity·María José MansillaCarmen Espejo
Mar 4, 2014·PloS One·Juan Jose Ramos-RodriguezMonica Garcia-Alloza
Sep 10, 2014·Journal of Diabetes Research·Jian-Qin WangYu-Hong Jing
Sep 13, 2014·Oxidative Medicine and Cellular Longevity·María MuriachJorge M Barcia
Mar 21, 2015·Clinical Interventions in Aging·Xiaohua LiSean X Leng
Aug 21, 2015·World Journal of Gastroenterology : WJG·Yukihito IshiiTakeshi Ohta
Sep 4, 2015·Neurology·Chris MoranUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Oct 4, 2017·Journal of Pharmacological and Toxicological Methods·Tatsuya MaekawaShinichi Kume

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
PCR

Software Mentioned

Image J

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.