Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats

Journal of Toxicologic Pathology
Yusuke KemmochiT Yamada

Abstract

Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity are known to be risk factors that exacerbate sarcopenia, but the underlying mechanism of diabetes-related sarcopenia is still unknown. Obese type 2 diabetes SDT fatty rats show early onset of severe diabetes and there have been no reports on the characteristics of their skeletal muscle. Therefore, pathophysiological analyses were performed for the skeletal muscle in these rats. Diabetic male SDT fatty rats were sacrificed at 8, 16, 24, 32 and 40 weeks of age. Age-matched Sprague Dawley (SD) rats were used as the normal control. In addition to biological blood parameters, the soleus and the extensor digitorum longus muscles were examined for muscle weight, histopathology, and protein synthesis and degradation. Muscle grip strength was also examined. These results revealed that the muscle weights of the SDT fatty rats were significantly decreased from 16 weeks of age. The mean cross-sectional area of muscle fibers in the SDT fatty rats decreased from 24 weeks of age. Increased intramyocellular lipid accumulation, identified by immunohistochemistry for adipophilin and TEM, was observed in the SDT fatty rats from 8 weeks of age. Plasma insulin-...Continue Reading

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Citations

Jan 29, 2020·The Journal of Experimental Biology·Guy A M MessaHans Degens
Oct 6, 2018·Journal of Cachexia, Sarcopenia and Muscle·Maria ConteStefano Salvioli
Jan 1, 2019·The Egyptian Journal of Neurology, Psychiatry and Neurosurgery·Hala ShaheenMohammed Gomaa
Aug 25, 2020·Journal of Diabetes Research·Kasumi KikuchiSusumu Ishida

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Methods Mentioned

BETA
ELISA
transmission electron microscopy
PCR
electron microscopy

Software Mentioned

ABI Prism 7700 Sequence Detection System
cellSens Standard

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