Pathophysiological and clinical aspects of iron chelation therapy in MDS

Current Pharmaceutical Design
Norbert Gattermann

Abstract

The majority of patients with myelodysplastic syndromes (MDS) become transfusion-dependent during the course of disease and may thus develop transfusional iron overload. As a further contributor to iron overload there is increased absorption of dietary iron from the gut, as a consequence of ineffective erythropoiesis. Compared with thalassemia, it is less clear how frequent patients with MDS develop clinical complications of iron overload, and whether the accumulation of iron shortens their survival. This review aims to summarize our current knowledge of the detrimental effects of transfusional iron overload in MDS, point out the risks associated with iron-induced oxidative stress, describe the tools available for diagnosing iron overload, indicate the treatment options with currently available iron chelators, and discuss the measurement of labile plasma iron (LPI) as a tool to monitor the efficacy of iron chelation therapy.

Citations

Jul 30, 2014·Hematology/oncology Clinics of North America·Sylvia S Bottomley, Mark D Fleming
Apr 1, 2015·British Journal of Haematology·Tiziana TataranniClaudia Piccoli
Apr 15, 2014·Free Radical Biology & Medicine·Thomas D Coates
Sep 3, 2013·Expert Review of Hematology·Mhairi MitchellAmer M Zeidan
Jan 23, 2019·Interactive Cardiovascular and Thoracic Surgery·Alexandro HoyerMaja-Theresa Dieterlen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Annals of Hematology
Norbert Gattermann, Eliezer A Rachmilewitz
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Christopher A Fausel
© 2021 Meta ULC. All rights reserved