Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma.

Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina
Gilberto Paz-FilhoMa-Li Wong

Abstract

To describe the pathophysiological basis linking cardiovascular disease (CVD) and depression; to discuss the causal relationship between them, and to review the effects of antidepressant treatment on cardiovascular disease. A review of the literature based on the PubMed database. Depression and cardiovascular disease are both highly prevalent. Several studies have shown that the two are closely related. They share common pathophysiological etiologies or co-morbidities, such as alterations in the hypothalamic-pituitary axis, cardiac rhythm disturbances, and hemorheologic, inflammatory and serotoninergic changes. Furthermore, antidepressant treatment is associated with worse cardiac outcomes (in case of tricyclics), which are not observed with selective serotonin reuptake inhibitors. Although there is a strong association between depression and cardiovascular disease, it is still unclear whether depression is actually a causal factor for CVD, or is a mere consequence, or whether both conditions share a common pathophysiological etiology. Nevertheless, both conditions must be treated concomitantly. Drugs other than tricyclics must be used, when needed, to treat the underlying depression and not as mere prophylactic of cardiac outc...Continue Reading

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Citations

Mar 15, 2019·CNS & Neurological Disorders Drug Targets·Maria PodsiedlikJoanna Sikora
Jan 7, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jessica L CastilhoTimothy R Sterling
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Mar 22, 2020·Journal of Cardiovascular Translational Research·Sher Ali KhanMuhammad Owais Abdul Ghani
Feb 2, 2019·International Journal of Psychiatry in Clinical Practice·Siegfried Kasper
Nov 12, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Whesley Tanor SilvaManoel Otávio da Costa Rocha
Feb 26, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jessica L CastilhoTimothy R Sterling
Apr 14, 2020·Current Neuropharmacology·Mervin Chávez-CastilloJoselyn Rojas-Quintero

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