Pathophysiological changes of the lower urinary tract behind voiding dysfunction in streptozotocin-induced long-term diabetic rats.

Scientific Reports
Kazuki MasudaHiroshi Fukuhara

Abstract

We evaluated pathophysiological characteristics of the lower urinary tract dysfunction in a streptozotocin (STZ)-induced diabetic rat model. STZ (60 mg/kg) was injected intraperitoneally into male Wistar rats. In vitro bladder muscle strip experiments, in vivo cystometry, and simultaneous recordings of bladder pressure + urethral perfusion pressure (BP + UPP) with or without intravenous administration of L-arginine (300 mg/kg) or tadalafil (0.03 mg/kg) were performed at several time points. In vitro muscle strip experiments demonstrated that diabetic rats had significantly higher contractile responses to carbachol at 4-16 weeks, and a tendency for higher contractile responses to electrical field stimulation at 4-12 weeks, but this was reversed at 16 weeks. Diabetic rats had significant increases in voided volume, residual volume, bladder capacity, maximal voiding pressure, and amplitude and frequency of non-voiding contractions at 16 weeks. Tadalafil decreased the residual volume in diabetic rats. Diabetic rats had significantly higher UPP nadir and mean UPP during high-frequency oscillation at 16 weeks, which were reversed by tadalafil or L-arginine administration. The present results suggest that urethral relaxation failure, ...Continue Reading

References

Apr 13, 2004·The Journal of Urology·Kazumasa TorimotoNaoki Yoshimura
Feb 16, 2005·The Journal of Urology·Kazumasa TorimotoNaoki Yoshimura
Mar 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Guiming Liu, Firouz Daneshgari
Oct 23, 2009·The Journal of Urology·Firouz DaneshgariJay Reeder
Mar 17, 2015·European Urology·Christopher R ChapplePhilip P Smith
Mar 8, 2016·Neurourology and Urodynamics·Gabriela MariniMarilza Vieira Cunha Rudge

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Citations

May 4, 2021·Frontiers in Pharmacology·Jianwu WangWeibing Li

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