Pathophysiological Characteristics Underlying Different Glucose Response Curves: A Latent Class Trajectory Analysis From the Prospective EGIR-RISC Study

Diabetes Care
Adam HulmanMelania Manco

Abstract

Glucose measurements during an oral glucose tolerance test (OGTT) are useful in predicting diabetes and its complications. However, knowledge of the pathophysiology underlying differences in glucose curve shapes is sparse. We examined the pathophysiological characteristics that create different glucose curve patterns and studied their stability and reproducibility over 3 years of follow-up. We analyzed data from participants without diabetes from the observational cohort from the European Group for the Study of Insulin Resistance: Relationship between Insulin Sensitivity and Cardiovascular Disease study; participants had a five-time point OGTT at baseline (n = 1,443) and after 3 years (n = 1,045). Measures of insulin sensitivity and secretion were assessed at baseline with a euglycemic-hyperinsulinemic clamp and intravenous glucose tolerance test. Heterogeneous glucose response patterns during the OGTT were identified using latent class trajectory analysis at baseline and at follow-up. Transitions between classes were analyzed with multinomial logistic regression models. We identified four different glucose response patterns, which differed with regard to insulin sensitivity and acute insulin response, obesity, and plasma level...Continue Reading

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Citations

Jan 9, 2019·Diabetes Care·Denise M ScholtensUNKNOWN HAPO Follow-Up Study Cooperative Research Group
Jan 24, 2020·The Journal of Clinical Endocrinology and Metabolism·Alfonso GalderisiSonia Caprio
Jul 15, 2020·American Journal of Physiology. Endocrinology and Metabolism·Joon Ha, Arthur Sherman
Oct 18, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·M OburaUNKNOWN IMI-DIRECT Consortium
Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ram JagannathanMichael Bergman
Mar 6, 2021·Frontiers in Bioengineering and Biotechnology·Natal A W van RielAlbert K Groen
Mar 12, 2021·PLoS Biology·Adam HulmanDaniel R Witte
Jun 26, 2021·World Journal of Diabetes·Feng Yu KuoJuei-Tang Cheng

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