Pathophysiological effects of dietary essential fatty acid balance on neural systems

Japanese Journal of Pharmacology
S YoshidaH Okuyama

Abstract

Dietary fatty acid balance has been revealed to affect neural functions as well as chronic diseases such as cancer, cerebro- and cardiovascular diseases, and allergic hyper-reactivity. In this review, we focused on the pathophysiological effects of n-6 and n-3 fatty acids on brain functions. Long-term n-3 fatty acid deficiency in the presence of n-6 fatty acids has been shown to affect learning behavior, drug sensitivity and retinal functions. Some membrane enzymes and ion channel functions have been shown in experimental animals to be regulated by membrane fatty acid modifications. We also summarized the effects of these fatty acids in diets on human psychotic aspects and brain diseases. Although biochemical mechanisms remain to be elucidated, investigations on the effect of dietary fatty acids on neural networks may provide an important clue to clarify complex brain functions.

References

Jul 1, 1976·Journal of the American Geriatrics Society·D HarmanJ Seibold
Jan 1, 1976·The Journal of Nutrition·M S Lamptey, B L Walker
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H HallaqA Leaf
Aug 1, 1991·Medical Hypotheses·R S Smith
Mar 1, 1991·Biological Psychiatry·S L DubovskyJ Murphy
Oct 8, 1990·Biochimica Et Biophysica Acta·P D Thomas, G J Brewer
Aug 1, 1988·The International Journal of Neuroscience·A RoyM Linnoila
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B L Scott, N G Bazan
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M NeuringerS Luck
Feb 1, 1986·Acta Neurologica Scandinavica·P J DelwaideM Ylieff
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L R Ballou, W Y Cheung
Aug 15, 1984·Biochimica Et Biophysica Acta·S Yoshida, M Takeshita
Oct 30, 1984·Biochemical and Biophysical Research Communications·S YoshidaA Kawaguchi
Feb 1, 1980·Neurology·D L Longo, J M Witherspoon
May 1, 1995·Journal of Psychiatric Research·M PeetG Reynolds
Oct 1, 1995·The American Journal of Clinical Nutrition·L J StevensJ R Burgess
Jul 1, 1995·The American Journal of Clinical Nutrition·J R Hibbeln, N Salem
Feb 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S PetrouJ J Singer
Nov 1, 1994·Developmental Psychobiology·P E WainwrightD McCutcheon
Jan 1, 1994·Metabolism: Clinical and Experimental·J B Young, M C Walgren
Jan 1, 1993·The Journal of Membrane Biology·G E TaffetR J Bick

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Citations

Jul 26, 2008·Journal of Experimental Botany·John D WilkieTrevor Olesen
Aug 13, 2009·European Journal of Pediatrics·Jan Philipp SchuchardtAndreas Hahn
Jun 17, 2006·International Review of Psychiatry·Malcolm R Garland, Brian Hallahan
Aug 11, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ella N SmitE Rudy Boersma
Aug 30, 2008·Journal of the American Dietetic Association·Cécilia SamieriPascale Barberger-Gateau
Sep 10, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L A Horrocks, Y K Yeo
Sep 6, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A J Richardson, B K Puri
Feb 9, 2002·The Journal of Nutritional Biochemistry·C DuH Okuyama
May 19, 2005·European Journal of Clinical Nutrition·P Barberger-GateauUNKNOWN 3C Study Group
Feb 21, 2002·Behavioural Brain Research·Martine OroscoValérie Daugé
Mar 26, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Lloyd A Horrocks, Akhlaq A Farooqui

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