Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models

Pain
Jan VollertRolf-Detlef Treede

Abstract

As an indirect approach to relate previously identified sensory phenotypes of patients suffering from peripheral neuropathic pain to underlying mechanisms, we used a published sorting algorithm to estimate the prevalence of denervation, peripheral and central sensitization in 657 healthy subjects undergoing experimental models of nerve block (NB) (compression block and topical lidocaine), primary hyperalgesia (PH) (sunburn and topical capsaicin), or secondary hyperalgesia (intradermal capsaicin and electrical high-frequency stimulation), and in 902 patients suffering from neuropathic pain. Some of the data have been previously published. Randomized split-half analysis verified a good concordance with a priori mechanistic sensory profile assignment in the training (79%, Cohen κ = 0.54, n = 265) and the test set (81%, Cohen κ = 0.56, n = 279). Nerve blocks were characterized by pronounced thermal and mechanical sensory loss, but also mild pinprick hyperalgesia and paradoxical heat sensations. Primary hyperalgesia was characterized by pronounced gain for heat, pressure and pinprick pain, and mild thermal sensory loss. Secondary hyperalgesia was characterized by pronounced pinprick hyperalgesia and mild thermal sensory loss. Topica...Continue Reading

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Citations

Jul 14, 2018·Current Opinion in Anaesthesiology·Julia ForstenpointnerRalf Baron
Jan 22, 2019·The Clinical Journal of Pain·Iris Weyer-Menkhoff, Jörn Lötsch
Feb 26, 2020·European Journal of Pain : EJP·Christine H Meyer-FrießemJan Vollert
Apr 28, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Sam W HughesPaul H Strutton
May 28, 2020·Breast Cancer Research and Treatment·L MustonenH Harno
Jun 26, 2020·Physiological Reviews·Nanna Brix FinnerupTroels Staehelin Jensen
Aug 15, 2020·European Journal of Pain : EJP·Paulina S ScheurenMichèle Hubli
Feb 23, 2019·European Journal of Pain : EJP·Pieter S SiebengaGeert J Groeneveld
May 16, 2019·Pain Practice : the Official Journal of World Institute of Pain·Munetaka Hirose, Yumiko Takao
Jun 30, 2019·Disease Models & Mechanisms·Lucie ValekIrmgard Tegeder
Jan 10, 2020·Annual Review of Pharmacology and Toxicology·Kirsty BannisterAnthony H Dickenson
Aug 11, 2020·Expert Opinion on Pharmacotherapy·Nebojsa Nick KnezevicIvana Knezevic
Jun 6, 2020·European Journal of Pain : EJP·Timothée CayrolEmanuel N van den Broeke
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Apr 1, 2019·European Journal of Pain : EJP·Rolf-Detlef TreedeAnke Tappe-Theodor
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Feb 10, 2020·Journal of Neural Transmission·Daniela C RosenbergerRolf-Detlef Treede
Jan 20, 2021·The Journal of Pain : Official Journal of the American Pain Society·Erzsebet MeheszSam W Hughes
Nov 7, 2020·International Journal of Environmental Research and Public Health·Cristina NaranjoInmaculada Failde
Dec 22, 2020·Diabetes Research and Clinical Practice·Ariel OdriozolaRayaz A Malik
Mar 3, 2020·Clinics in Plastic Surgery·Lauren JacobsonAmy M Moore
Mar 25, 2021·European Journal of Pain : EJP·Charles QuesadaLuis Garcia-Larrea

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