PMID: 2446063Jan 1, 1987

Pathophysiological relevance of serotonin

Journal of Cardiovascular Pharmacology
P A van Zwieten

Abstract

The present article deals with the pathophysiological role of serotonin in cardiovascular disease and in other disorders that are accompanied by cardiovascular pathophysiological events. The distribution of serotonin over various organs and tissues and the presence of several types of 5-HT receptors would suggest a rather important physiological role of serotonin. However, a modest serotonergic role could only be shown for the microcirculation and for the regional circulation of the brain and the intestinal wall. An important pathological role of serotonin in the carcinoid syndrome, in migraine, and in peripheral vascular disease is beyond debate, although many details remain to be established. The possibility that serotonergic mechanisms contribute to Raynaud's phenomenon and other vasospastic disorders is the subject of present discussions, although firm evidence for this view is not widely available. An involvement of peripheral serotonin in the genesis and maintenance of essential hypertension seems very unlikely, although vascular damage due to hypertension is probably enhanced by serotonin released from aggregating platelets. This ancillary process is, in particular, to be anticipated in older patients, with vascular wall...Continue Reading

References

Jul 15, 1996·Thrombosis Research·D PawlakM Mysliwiec
Sep 1, 1996·Thrombosis Research·J MalyszkoM Mysliwiec
Feb 11, 2000·Veterinary Parasitology·A P Yatsuda, M C Vieira-Bressan
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Related Concepts

Carcinoid Tumor
Serotonin Measurement
Blood Vessel
Serotonin
Brain
Receptors, Tryptamine
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Regional Blood Flow
Essential Hypertension
Organ

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