Pathophysiological significance of protein hydrophobic interactions: An emerging hypothesis

Medical Hypotheses
Marek Kieliszek, Boguslaw Lipinski

Abstract

Fibrinogen is a unique protein that is converted into an insoluble fibrin in a single enzymatic event, which is a characteristic feature of fibrinogen due to its susceptibility to fibrinolytic degradation and dissolution. Although thrombosis is a result of activated blood coagulation, no explanation is being offered for the persistent presence of fibrin deposits in the affected organs. A classic example is stroke, in which the thrombolytic therapy is effective only during the first 3-4 h after the onset of thrombosis. This phenomenon can now be explained in terms of the modification of fibrinogen structure induced by hydroxyl radicals generated during the period of ischemia caused, in turn, by the blocking of the blood flow within the obstructed vessels. Fibrinogen modification involves intra-to intermolecular disulfide rearrangement induced by the reductive power of hydroxyl radicals that result in the exposition of buried hydrophobic epitopes. Such epitopes react readily with each other forming linkages stronger than the peptide covalent bonds, thus rendering them resistant to the proteolytic degradation. Also, limited reduction of human serum albumin (HSA) generates hydrophobic polymers that form huge insoluble complexes wit...Continue Reading

Citations

Sep 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Changjiao GanGuifang Dou
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yongjie XiongShaojun He
Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marek Kieliszek
Jul 30, 2020·International Journal of Molecular Sciences·Marek KieliszekJoanna Szpunar
Feb 9, 2019·Molecular Biology Reports·Marek KieliszekAnna M Kot
Oct 28, 2019·International Journal of Molecular Sciences·Marco CalvarusoLuigi Minafra
Jan 16, 2020·Antioxidants·Ana Carolina RuberteCarmen Sanmartín
Sep 13, 2018·International Journal of Molecular Sciences·Mikko J Lammi, Chengjuan Qu
May 29, 2020·Medical Hypotheses·Marek Kieliszek, Boguslaw Lipinski
Jun 3, 2021·Antioxidants·Gorka Calvo-MartínCarmen Sanmartín

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Current Drug Targets
Etheresia PretoriusBoguslaw Lipinski
Current Neurovascular Research
Boguslaw Lipinski, Etheresia Pretorius
Ultrastructural Pathology
Boguslaw LipinskiWendy J van der Spuy
Microscopy Research and Technique
Boguslaw LipinskiWendy Jeanette Van Der Spuy
© 2022 Meta ULC. All rights reserved