Pathophysiological Study of Sensitive Skin

Acta Dermato-venereologica
Virginie BuhéLaurent Misery

Abstract

Sensitive skin is a clinical syndrome characterized by the occurrence of unpleasant sensations, such as pruritus, burning or pain, in response to various factors, including skincare products, water, cold, heat, or other physical and/or chemical factors. Although these symptoms suggest inflammation and the activation of peripheral innervation, the pathophysiogeny of sensitive skin remains unknown. We systematically analysed cutaneous biopsies from 50 healthy women with non-sensitive or sensitive skin and demonstrated that the intraepidermal nerve fibre density, especially that of peptidergic C-fibres, was lower in the sensitive skin group. These fibres are involved in pain, itching and temperature perception, and their degeneration may promote allodynia and similar symptoms. These results suggest that the pathophysiology of skin sensitivity resembles that of neuropathic pruritus within the context of small fibre neuropathy, and that environmental factors may alter skin innervation.

Citations

Sep 23, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·R J H RichtersP C M van de Kerkhof
Oct 27, 2016·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Y-F MaP Humbert
Jan 12, 2017·Cutaneous and Ocular Toxicology·Douglas M FrederickAnnahita Ghassemi
May 22, 2018·Experimental Dermatology·Sophie Seite, Laurent Misery
Jul 20, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·L MiseryC Taieb
Mar 25, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·L MiseryC Taieb
Jun 27, 2019·Experimental Dermatology·Flavien Huet, Laurent Misery
Jun 18, 2016·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M P PereiraS Ständer
Oct 2, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·Emilie BrenautAnne-Sophie Ficheux
Mar 1, 2020·Journal of Cosmetic Dermatology·Ji Yeon HongKui Young Park
Jul 12, 2019·PloS One·Takashi SakamotoTakefumi Kikusui
Apr 4, 2017·Brain : a Journal of Neurology·Sofia von BischhoffshausenMargarita Calvo
Jun 14, 2019·Frontiers in Medicine·Adeline BatailleLaurent Misery
Dec 27, 2016·Plastic and Reconstructive Surgery. Global Open·Katie RodanTimothy Falla
Jun 4, 2019·Frontiers in Medicine·Miranda A Farage
Oct 30, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·L MiseryUNKNOWN Special Interest Group on sensitive skin of the International Forum for the Study of Itch (ISFI)
Aug 6, 2019·Frontiers in Medicine·Martin Schmelz
Jun 6, 2019·Frontiers in Medicine·Matthieu Talagas, Laurent Misery
Jul 20, 2019·Annales de dermatologie et de vénéréologie·L Misery
Mar 6, 2019·Annales de dermatologie et de vénéréologie·L Misery
Apr 10, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·T LugerT Bieber
Aug 29, 2021·Pharmaceuticals·Diana I S P ResendeIsabel Filipa Almeida
Sep 24, 2021·Journal of Cosmetic Dermatology·Monica CorazzaAlessandro Borghi
Jul 23, 2021·The Journal of Investigative Dermatology·Jérémy ChéretRalf Paus

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