PMID: 8939182Nov 1, 1996Paper

Pathophysiology and clinical presentations of cough

The Journal of Allergy and Clinical Immunology
U G LallooK F Chung

Abstract

The human cough reflex is still poorly understood, although it is known to occur independently of bronchoconstriction. Sensitization of the cough reflex is a unifying hypothesis for chronic dry cough in several conditions, including gastroesophageal acid reflux, angiotensin-converting enzyme inhibitor cough, and cough-variant asthma. The most common cause of chronic dry cough is a group of related conditions of chronic rhinitis, sinusitis, and postnasal drip. In these cases the cough reflex may be sensitized through an action of inflammatory mediators from the nasal mucosa on the airways or a reflex sensitization of airway sensory nerves. The association of cough with gastroesophageal reflux may occur through a local esophageal-tracheobronchial reflex. Angiotensin-converting enzyme inhibitor cough is a side effect of treatment in about 10% of patients; it probably results from inhibition of the degradation of kinins, particularly bradykinin, in the airway. Why some patients with asthma have cough as the principal feature of their disease is unclear. Tachykinins are probably involved in the mechanism of sensitization of the cough reflex, and the development of neuropeptide antagonists may open new research opportunities. A study...Continue Reading

Citations

Feb 13, 2001·European Journal of Pharmacology·I Greczko, T Tyrakowski
Jun 18, 1998·Otolaryngologic Clinics of North America·V M Tsou, P R Bishop
Jul 10, 2003·Pulmonary Pharmacology & Therapeutics·R PecovaM Tatar
Jul 25, 2008·Nature·Stephen J GalliAdrian M Piliponsky
Mar 3, 2009·Cephalalgia : an International Journal of Headache·H C DienerG Davidai
Jul 19, 2012·Der Internist·A R KoczullaC Vogelmeier
May 1, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Toshihiro ShiraiKingo Chida
Apr 6, 2004·Clinics in Chest Medicine·K Suresh Babu, Benjamin G Marshall
Jun 27, 2002·Expert Opinion on Investigational Drugs·K F Chung
May 26, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Mitsuhiro KamimuraKoichiro Kudo
Jan 13, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Sara J BonviniMaria G Belvisi
Mar 12, 2003·Chest·Umesh G Lalloo
Jul 16, 1999·Pediatric Pulmonology·A B Chang
Sep 20, 2007·Journal of Cardiovascular Pharmacology·Philippe DaullBruno Battistini
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Erling TronvikGunnar Bovim
May 1, 2002·Current Protocols in Pharmacology·Brendan J Canning
Apr 16, 2020·BMC Pulmonary Medicine·Jiaxing XieKefang Lai
Feb 17, 2001·Pediatric Pulmonology·S G Campanella, M I Asher

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