PMID: 11918520Mar 29, 2002Paper

Pathophysiology and first-line treatment of osteoarthritis

The Annals of Pharmacotherapy
Jesse H Hogue, Tracey L Mersfelder

Abstract

To review the pathophysiology of osteoarthritis (OA) and the various treatment modalities, focusing specifically on acetaminophen (APAP), nonsteroidal antiinflammatory drugs (NSAIDs), and cyclooxygenase-2 (COX-2) inhibitors as the primary treatment options. Primary literature and tertiary references were identified by a MEDLINE search (1966-March 2001) and through other secondary sources. After evaluating the articles and references identified from the data sources, all the information that was judged relevant by the reviewers was included in the review article. OA is the most common joint disorder worldwide. Current research suggests that factors such as inflammation and changes in subchondral bone may play a larger role in the pathophysiology than previously thought. With this research and the development of COX-2 inhibitors, selecting the medication of choice for OA has become difficult. More research needs to be done before the pathophysiology of OA can be clearly determined. In the meantime, treatment should be based on clinical data and patient response. Studies have shown that APAP and NSAIDs have comparable efficacy, as do traditional NSAIDs and COX-2 inhibitors. APAP is associated with fewer toxicities than are the tra...Continue Reading

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Citations

Sep 10, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Darvin J GriffinLawrence J Bonassar
Feb 20, 2004·Osteoarthritis and Cartilage·Wen-Fu T LaiChing-Hsuan Tung
Jul 4, 2006·Biochimica Et Biophysica Acta·Xiaohong BiNancy Pleshko Camacho
Feb 5, 2004·Drugs·Kenneth Brandt

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