PMID: 8593298Oct 1, 1995Paper

Pathophysiology and postnatal pathogenesis of hypoplastic kidney (hpk/hpk) in the male hypogonadic mutant rat (hgn/hgn)

The Journal of Veterinary Medical Science
H Suzuki, K Suzuki

Abstract

The male hypogonadic rate (hgn/hgn) is accompanied with bilateral hypoplastic kidney (HPK; hpk/hpk)[34]. In this study, we examined the kidney weight (KW), glomerular number (GN), renal pathohistology at adult (80 days of age), and pathogenesis during the early postnatal stage in the hpk/hpk, +/hpk, and +/+ rat. The GN of adult hpk/hpk was significantly less that that of the +/hpk and +/+. Histologically, there were the decreased number of nephrons and the associated secondary changes in the hpk/hpk kidney. The plasma concentrations of urea nitrogen and creatinine were significantly higher in the hpk/hpk than in the +/hpk and +/+. During early postnatal stage, the KW of the hpk/hpk was significantly smaller than those of the +/hpk and +/+, and the GN was fewer in order of the hpk/hpk, +/hpk and +/+, showing the significant differences between given genotypes. The layer of nephrogenic nephron beneath the renal capsula of the neonatal kidney appeared to be thinner in the hpk/hpk than in the normal (+/hpk and +/+). In the hpk/hpk kidney on 3 days of age, the layer of the nephrogenic nephron was absent in some portions beneath the renal capsula. In the hpk/hpk kidney on 7 days of age, further, the layer of immature type of nephron ...Continue Reading

Citations

Jul 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Hiroetsu SuzukiKatsushi Suzuki
Mar 31, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hiroetsu SuzukiKatsushi Suzuki
May 5, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hiroetsu SuzukiKatsushi Suzuki
Jun 1, 2012·Toxicologic Pathology·Kendall S FrazierAxel Bube
Oct 9, 2004·The Journal of Veterinary Medical Science·Hiroetsu SuzukiKatsushi Suzuki
Feb 11, 2011·The Journal of Veterinary Medical Science·Kohei AmakasuHiroetsu Suzuki

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