Pathophysiology, mechanisms and applications of mesenchymal stem cells for the treatment of spinal cord injury

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Pravin Shende, Muna Subedi

Abstract

Spinal Cord Injury (SCI) is a serious devastating condition associated to the high chances of morbidity and mortality. It involves a primary and a secondary injury, former cause damages to both lower and upper motor neurones and disrupts sensory, motor and autonomic functions while the latter involves various stages of molecular plus cellular incidents which elaborate the original injury. In the treatment of SCI, stem cells possess a good therapeutic potential. Bone marrow, adipose tissue, placenta, amniotic fluid and umbilical cord are the good sources for mesenchymal stem cells. This review article shows the uses of bone marrow derived mesenchymal cells in the treatment of acute and chronic case of SCI and its future scope.

Citations

May 23, 2019·Stem Cell Research & Therapy·Kyan James AllahdadiMilena Botelho Pereira Soares
Dec 11, 2019·Journal of Tissue Engineering and Regenerative Medicine·Alfredo Maqueda, Francisco J Rodriguez
Jan 22, 2020·Journal of Drug Targeting·Pravin Shende, Varun S Wakade
Apr 23, 2019·Current Opinion in Urology·Edoardo PozziUNKNOWN Trauma, Reconstructive Urology Working Party of the European Association of Urology (EAU) Young Academic Urologists (YAU)
Nov 9, 2020·Stem Cell Reviews and Reports·Drashti Desai, Pravin Shende
Feb 11, 2021·Journal of Chemical Neuroanatomy·Saeed Vafaei-NezhadHojjat Allah Abbaszadeh
Jan 21, 2021·Frontiers in Cell and Developmental Biology·Shihua H WangRobert Chunhua Zhao
May 10, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Nazneen Pathan, Pravin Shende
Jul 23, 2021·ACS Biomaterials Science & Engineering·Alexander HalimNing-Ping Huang

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