PMID: 11605169Oct 18, 2001Paper

Pathophysiology of alpha- and beta-thalassemia: therapeutic implications

Seminars in Hematology
D Rund, Eliezer Rachmilewitz

Abstract

At the molecular level, the underlying cause of thalassemia is any of a number of genetic lesions that reduce or abolish the production of the globin chains of hemoglobin. The resulting chain imbalance is the key factor initiating the damage to the red blood cell (RBC) and it is the major pathophysiological event in all forms of the thalassemia syndromes. In this review we will outline some of the cellular and systemic processes that have been implicated in the development of the disease. When relevant, we will discuss the ways in which these processes can be altered in a therapeutic manner.

References

Jan 1, 1979·American Journal of Hematology·G GrahamC Hershko
Oct 1, 1978·British Journal of Haematology·C HershkoE A Rachmilewitz
Jul 7, 1992·Biochimica Et Biophysica Acta·L N GrinbergE A Rachmilewitz
Feb 1, 1989·The Journal of Clinical Investigation·E ShinarS E Lux
Oct 1, 1989·American Journal of Hematology·A EldorA D Heyns
Mar 1, 1987·European Journal of Haematology·P LamchiagdhaseS Fucharoen
Jan 1, 1974·Annals of the New York Academy of Sciences·A PolliackE A Rachmilewitz
Mar 1, 1973·British Journal of Haematology·A Polliack, E A Rachmilewitz
Jan 1, 1970·Medicine·C A FinchE R Biblett
Jun 1, 1993·Baillière's Clinical Haematology·E Shinar, E A Rachmilewitz
Aug 17, 1994·Biochemical Pharmacology·L N GrinbergH Newmark
Mar 1, 1993·Baillière's Clinical Haematology·D R Higgs
Mar 1, 1995·Free Radical Biology & Medicine·L N GrinbergM Chevion
Nov 27, 1997·The New England Journal of Medicine·A SoloveyR P Hebbel
Nov 28, 1997·Biochemical Pharmacology·L N GrinbergE A Rachmilewitz
May 12, 1998·Hemoglobin·T H Huisman, M F Carver
Jun 13, 1998·The Journal of Clinical Investigation·A SoloveyR P Hebbel
Aug 12, 1999·British Journal of Haematology·T HovavG Barshtein

❮ Previous
Next ❯

Citations

Nov 15, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Keith Al-HasaniPanayiotis A Ioannou
Sep 8, 2011·Asian Journal of Transfusion Science·Azita AzarkeivanMohammad Hadizadeh
Apr 15, 2011·Biochemistry Research International·Maria Emília Favero, Fernando Ferreira Costa
Sep 11, 2007·Journal of Diabetes and Its Complications·Viroj Wiwanitkit
Feb 13, 2003·Pediatric Clinics of North America·Louise Lo, Sylvia Titi Singer
Apr 22, 2017·Case Reports in Neurological Medicine·Behnaz AnsariAli Asghar Okhovat
Aug 23, 2011·Pediatric Hematology and Oncology·Azita AzarkeivanMitra Salahmand
Nov 1, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Grace Isobel DaviesDonald Bowden
Nov 18, 2005·European Journal of Gastroenterology & Hepatology·Mehran KarimiZahra Hashemi
Nov 30, 2006·British Journal of Haematology·Lynn Quek, Swee Lay Thein
Aug 30, 2008·Pediatric Hematology and Oncology·Azita AzarkeivanParvaneh Vosough
Sep 16, 2005·The New England Journal of Medicine·Deborah Rund, Eliezer Rachmilewitz
May 6, 2008·Experimental Hematology·Natasha SzuberPrem Ponka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.