PMID: 12787713Jun 6, 2003Paper

Pathophysiology of bone metastases from prostate cancer and the role of bisphosphonates in treatment

Cancer Treatment Reviews
Colby L Eaton, R E Coleman

Abstract

Metastasis to bone is a common feature in advanced prostate cancer patients. Current treatments, while effective in suppressing tumour growth and relieving tumour associated bone pain, do not provide long term remission or 'cure' for the disease. A greater understanding of prostate cancer metastasis is required if new treatment strategies are to be developed. Growth of tumour foci in skeletal sites is a major cause of morbidity in advanced prostate cancer and has required the development of specialised approaches to treatment, including the use of bisphosphonates. These drugs inhibit tumour induced osteoclastic bone resorption, thereby preventing skeletal related events and treatment induced bone loss. Zoledronic acid is currently the only bisphosphonate with proven benefit in prostate cancer. Bisphosphonates may also modify the bone microenvironment so that it becomes less favourable for the growth and survival of metastases. The most recent developments in our understanding of the advantages for growth and survival gained by metastatic prostate cancer cells in the skeleton are reviewed, along with the clinical evidence supporting the use of bisphosphonates in advanced prostate cancer.

References

Jul 1, 1991·British Journal of Urology·N W ClarkeN J George
Aug 27, 1987·The New England Journal of Medicine·I R GarrettG R Mundy
Dec 1, 1985·British Journal of Urology·G H UrwinJ A Kanis
Nov 14, 1974·The New England Journal of Medicine·G R MundyS E Salmon
Apr 18, 1974·The New England Journal of Medicine·G R MundyD N Buell
Dec 1, 1982·British Journal of Haematology·A Valentin-OpranM E Arlot
Jul 1, 1995·British Journal of Haematology·R BatailleM Basle
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T TamuraT Taga
May 1, 1996·British Journal of Haematology·M C KyrtsonisA Maniatis
Jan 1, 1995·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G PoórL J Melton
Feb 5, 1998·Journal of the National Cancer Institute·J E Lehr, K J Pienta
Apr 16, 1998·Journal of the National Cancer Institute·A Grothey, P D McCrea
Mar 29, 2002·British Journal of Haematology·Sophie RouxXavier Mariette
Oct 3, 2002·Journal of the National Cancer Institute·Fred SaadUNKNOWN Zoledronic Acid Prostate Cancer Study Group
Oct 31, 2002·Statistics in Medicine·Arduino VerdecchiaRiccardo Capocaccia
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·A HeidenreichR Hofmann
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D S ErnstW Parulekar

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Citations

May 23, 2006·Clinical & Experimental Metastasis·S H Tannehill-GreggT J Rosol
Nov 18, 2008·Endocrine·Bandana ChakravartiNaibedya Chattopadhyay
May 21, 2010·BMC Urology·Ary Serpa NetoAuro Del Giglio
Nov 17, 2007·Clinical & Experimental Metastasis·Jeroen T BuijsGabri van der Pluijm
Dec 17, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·T Lebret, A Méjean
Oct 9, 2007·Clinical Breast Cancer·Joanne E MortimerJoseph D Kohles
Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Klaus JungDietmar Schnorr
Dec 15, 2006·BJU International·Ian VelaDavid L Nicol
Oct 27, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Puja Sarkar, Sudhir Kumar
Jul 25, 2006·Expert Opinion on Pharmacotherapy·Pete Anderson
Apr 1, 2005·Neoplasia : an International Journal for Oncology Research·Izabela PodgorskiBonnie F Sloane
Aug 25, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Thomas MückeMark Thalgott
Jul 8, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Layka A AsbaghCag Cal
Oct 21, 2006·The Cochrane Database of Systematic Reviews·K K YuenM D Mason
Oct 26, 2011·International Journal of Cancer. Journal International Du Cancer·Sivan IzraelyIsaac P Witz
Aug 1, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundeep KhoslaUNKNOWN American Society for Bone and Mineral Research
Jan 11, 2019·Contrast Media & Molecular Imaging·Manuel ScimecaElena Bonanno
Jul 20, 2007·Biochemical Society Transactions·N A CrossC L Eaton
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shan LuZhongyun Dong
Apr 6, 2005·Clinical Breast Cancer·Theresa A GuiseJohn M Chirgwin

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