Pathophysiology of bone metastases from solid malignancies

Joint, Bone, Spine : Revue Du Rhumatisme
Philippe Clezardin

Abstract

Bone metastases are common complications of many cancers. Among the mechanisms that set the scene for the development of bone metastases, several are shared by all forms of metastatic dissemination (pre-metastatic niche formation and chemotactic attraction of malignant cells, which invade the host tissue) and others are specific of bone tissue (homing of malignant cells to bone marrow niches and acquisition of an osteomimetic cell phenotype). After a latency period that can last several years, the malignant cells can proliferate into tumors that alter the normal bone remodeling process by inducing dysregulation of osteoblast and osteoclast function. These metastases may be lytic, characterized by major bone destruction; sclerotic, with excess bone formation; or mixed. Osteolysis occurs when the tumor cells stimulate osteoclast activity and inhibit osteoblast activity, whereas the opposite effects lead to bone sclerosis. Moreover, the mineralized bone matrix plays a major role in the formation of bone metastases, as its degradation releases growth factors and calcium that exert mitogenic effects on tumor cells. Thus, bone metastases are the site of a vicious circle in which mechanisms involved in bone resorption/formation promot...Continue Reading

References

Jul 2, 2004·Nature Reviews. Cancer·Fran Balkwill
Jan 5, 2005·Nature Reviews. Cancer·Christopher J Logothetis, Sue-Hwa Lin
Jan 14, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yan-Xi SunRussell S Taichman
Oct 10, 2006·Breast Cancer Research and Treatment·A BellahcèneV Castronovo
Oct 19, 2007·Cancer Research·Céline Le GallPhilippe Clézardin
Aug 19, 2008·Molecular Cancer Research : MCR·Khoi ChuSue-Hwa Lin
Mar 25, 2009·Nature Reviews. Cancer·Don X NguyenJoan Massagué
Feb 26, 2010·The Journal of Biological Chemistry·Takumi MaruhashiAkira Kudo
Mar 26, 2011·Science·Christine L Chaffer, Robert A Weinberg
May 19, 2011·Breast Cancer Research : BCR·Philippe Clézardin
May 20, 2011·Nature Reviews. Cancer·Katherine N WeilbaecherLaurie K McCauley
May 1, 2012·Nature Reviews. Drug Discovery·David L LaceyRoger Dansey
Jul 20, 2012·Nature Reviews. Cancer·Holly E BarkerJanine T Erler
May 3, 2013·PloS One·Russell S TaichmanKenneth J Pienta
Mar 13, 2014·Cell Stem Cell·Thordur OskarssonJoan Massagué
Mar 13, 2014·International Journal of Cancer. Journal International Du Cancer·Richard BachelierPhilippe Clézardin
Mar 13, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Martine CrosetPhilippe Clézardin
Aug 15, 2014·Nature Reviews. Cancer·María Soledad SosaJulio A Aguirre-Ghiso
Jan 24, 2015·Nature Reviews. Cancer·Anne R BresnickDanna B Zimmer
May 20, 2015·BoneKEy Reports·Martine CrosetPhilippe Clézardin
Nov 3, 2015·Nature·Ayuko HoshinoDavid Lyden
Nov 27, 2015·Biochimica Et Biophysica Acta·Samawansha TennakoonEnikö Kállay
May 26, 2016·Nature Reviews. Cancer·Peter I CroucherT John Martin

❮ Previous
Next ❯

Citations

Apr 15, 2020·Future Oncology·Chengtong LiangChuanli Ren
Mar 3, 2019·Cancer Metastasis Reviews·Sofia AvnetNicola Baldini
Oct 18, 2020·International Journal of Molecular Sciences·Jessica JannNathalie Faucheux
Apr 10, 2018·Joint, Bone, Spine : Revue Du Rhumatisme·Cyrille B ConfavreuxNicolas Girard
May 1, 2021·Journal of Clinical Medicine·Angelica PetrilloBruno Daniele
Jun 3, 2021·International Journal of Molecular Sciences·Elise AasebøØystein Bruserud
Aug 8, 2021·International Journal of Molecular Sciences·Liberato GiardulloFrancesco Paolo Cantatore
Oct 12, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F Lopez-CamposA Conde-Moreno

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.