Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation

Immunology and Allergy Clinics of North America
Adela Rambi G Cardones, R P Hall

Abstract

Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease in which antigen presentation in the gastrointestinal mucosa results in cutaneous IgA deposition and distinct, neutrophil-driven cutaneous lesions. Our findings suggest that the qualitatively different immune response to gluten in the intestinal mucosa of patients with DH results in minimal clinical symptoms, allowing the continued ingestion of gluten and the eventual development of DH. Our model may provide a new way to understand the pathogenesis of other skin diseases associated with gastrointestinal inflammation such as pyoderma gangrenosum or erythema nodosum, or explain association of seronegative inflammatory arthritis with inflammatory bowel disease.

References

Dec 1, 1978·The British Journal of Dermatology·I J KarlssonJ M Marks
Feb 1, 1977·Archives of Dermatology·S I KatzW Strober
Jan 1, 1992·Clinical Immunology and Immunopathology·R P Hall, K D McKenzie
Oct 1, 1987·Journal of the American Academy of Dermatology·L J Meyer, J J Zone
Jul 1, 1986·Oral Surgery, Oral Medicine, and Oral Pathology·P Economopoulou, G Laskaris
Mar 1, 1985·Scandinavian Journal of Gastroenterology·R GillbergC Ahren
Nov 1, 1973·The British Journal of Dermatology·N G FraserD Donald
Jun 1, 1972·The Journal of Clinical Investigation·Z M FalchukW Strober
Nov 1, 1972·The Journal of Clinical Investigation·S I KatzW Strober
Apr 7, 1983·The New England Journal of Medicine·J LeonardL Fry
Jul 8, 1983·JAMA : the Journal of the American Medical Association·L A Duhring
Jan 1, 1983·British Medical Journal·J N LeonardL Fry
Sep 1, 1983·Clinical and Experimental Dermatology·D B BuckleyM J Whelton
Feb 1, 1984·Gut·D J GawkrodgerR S Barnetson
Jul 1, 1982·Oral Surgery, Oral Medicine, and Oral Pathology·R J NisengardL Kryst
Aug 1, 1980·The Journal of Dermatology·K HashimotoM Matsuyama
Dec 1, 1982·The British Journal of Dermatology·L FryR M McMinn
Dec 1, 1994·Pediatric Dermatology·T W McGovern, S D Bennion
Jan 1, 1994·Dermatology : International Journal for Clinical and Investigative Dermatology·M L McCord, R P Hall
Jan 1, 1995·Dermatology : International Journal for Clinical and Investigative Dermatology·K ShimizuT Nishikawa
Mar 1, 1996·The British Journal of Dermatology·T Reunala
Mar 1, 1997·The British Journal of Dermatology·T Reunala, P Collin
Oct 28, 1998·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·D S MilstoneM A Gimbrone
Feb 9, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·M ShibaharaH Shimizu
Mar 20, 2002·The Journal of Experimental Medicine·Miklós SárdyNeil Smyth
Jul 27, 2002·The American Journal of Dermatopathology·Simon J P Warren, Clay J Cockerell
Nov 28, 2002·The British Journal of Dermatology·A D SmithR P Hall
Jan 13, 2004·Experimental Dermatology·Fumiko TakeuchiRussell P Hall
Jan 15, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·K PreiszS Kárpáti
Jan 20, 2005·The British Journal of Dermatology·K HervonenT Reunala
Apr 22, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M ViljamaaP Collin
Jan 6, 2007·The Journal of Investigative Dermatology·Matthew R DonaldsonLaurence J Meyer
Jun 29, 2007·The Journal of Investigative Dermatology·Russell P HallRobert D Streilein
Sep 8, 2007·International Journal of Dermatology·Javier Alonso-LlamazaresRoy S Rogers
Mar 5, 2008·Alimentary Pharmacology & Therapeutics·N R LewisJ West
May 28, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·S C HofmannL Bruckner-Tuderman
Jun 12, 2009·The Journal of Investigative Dermatology·Troy D JaskowskiChristopher M Hull
Nov 19, 2009·Journal of Cutaneous Pathology·Christine J KoJennifer M McNiff
Dec 18, 2009·Clinical and Experimental Dermatology·S FlannS E Munn

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