Pathophysiology of diverticular disease

Expert Review of Gastroenterology & Hepatology
Kathleen M SchiefferWalter A Koltun

Abstract

Inflammation of diverticula, or outpouchings of the colonic mucosa and submucosa through the muscularis layer, leads to diverticulitis. The development of diverticular disease, encompassing both diverticulosis and diverticulitis, is a result of genetic predisposition, lifestyle, and environmental factors, including the microbiome. Areas covered: Previous reports implicated genetic predisposition, environmental factors, and colonic dysmotility in diverticular disease. Recent studies have associated specific host immune responses and the microbiome as contributors to diverticulitis. To review pertinent literature describing pathophysiological factors associated with diverticulosis or diverticulitis, we searched the PubMed database (March 2018) for articles considering the role of colonic architecture, genetic predisposition, environment, colonic motility, immune response, and the microbiome. Expert commentary: In the recent years, research into the molecular underpinnings of diverticular disease has enhanced our understanding of diverticular disease pathogenesis. Although acute uncomplicated diverticulitis is treated with broad spectrum antibiotics, evaluation of the microbiome has been limited and requires further comprehensive ...Continue Reading

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Citations

Mar 29, 2020·Nature Reviews. Disease Primers·Antonio TursiSilvio Danese
Jul 9, 2020·International Journal of Molecular Sciences·Noha Ahmed Nasef, Sunali Mehta
Jan 8, 2021·International Journal of Colorectal Disease·Aikaterini MastorakiEvangelos Felekouras
Nov 7, 2020·International Journal of Colorectal Disease·Alexandra M Zaborowski, Des C Winter
Feb 10, 2021·Journal of Digestive Diseases·Nihat GulaydinFeyzullah Ersoz
Mar 16, 2021·Seminars in Colon & Rectal Surgery·Lillias Maguire
Apr 1, 2021·Digestive Diseases and Sciences·Greg A TurnerFrank A Frizelle
Jul 14, 2021·The Journal of Surgical Research·Kathleen M SchiefferWalter A Koltun
Aug 18, 2021·Annals of Medicine and Surgery·Karthik KanamallaJose Vargas

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