PMID: 25782197Jan 1, 2014Paper

Pathophysiology of hypertension in chronic kidney disease

Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
Magdalena Sawicka, Mirosław Jędras

Abstract

Hypertension is both an important cause and consequence of chronic kidney disease (CKD). It is present in 80-85% of the patients. The article summarizes the main pathogenetic factors of hypertension in CKD such as: sodium retention, increased activity the renin-angiotensin-aldosterone system and sympathetic nervous system, impaired nitric oxide synthesis and endothelium-mediated vasodilatation, oxidative stress, disorders of calcium metabolism and parathyroid hormone secretion, vascular calcification and increased arterial stiffness.

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