Pathophysiology of interleukin-1 receptor-associated kinase-M: implications in refractory state

Current Opinion in Infectious Diseases
Eduardo López-CollazoCarlos del Fresno

Abstract

The pseudo-kinase interleukin-1 receptor-associated kinase-M has emerged as a critical molecule in the down-regulation of inflammatory responses. Dysregulation of the toll-like receptor-interleukin-1 receptor-associated kinase system, and in particular interleukin-1 receptor-associated kinase-M up-regulation, are associated with a number of pathologies. This review highlights recent findings on interleukin-1 receptor-associated kinase-M reported in biomedical literature. Interleukin-1 receptor-associated kinase-M plays a critical role in generating a refractory state of the immune system following monocytes/macrophages encounter with bacteria or tumor cells. This state has been demonstrated so far in patients who suffer from sepsis, leukemia, and acute coronary syndrome, and seems to be associated with interleukin-1 receptor-associated kinase-M overexpression in their circulating monocytes. In addition, the pseudo-kinase represents a central regulator of osteoclast differentiation and activation, and might thus be related to the onset of osteoporosis. Interleukin-1 receptor-associated kinase-M is involved in the control of endotoxin tolerance in monocytes, in osteoporosis, as well as in the deactivation of tumor-infiltrating ma...Continue Reading

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Citations

Mar 16, 2012·Immunologic Research·Subhra K BiswasJyue-Yuan Lim
Sep 29, 2012·The Journal of Biological Chemistry·Kyoung-Hee LeeKoichi S Kobayashi
Nov 16, 2013·Critical Care : the Official Journal of the Critical Care Forum·Eduardo López-Collazo, Carlos del Fresno
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Sep 29, 2009·Trends in Immunology·Subhra K Biswas, Eduardo Lopez-Collazo
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May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos del FresnoEduardo López-Collazo
Mar 31, 2012·Journal of Leukocyte Biology·Vanesa Gómez-PiñaEduardo López-Collazo
Sep 17, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carolina Cubillos-ZapataEduardo López-Collazo
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Subhra K BiswasVinay Tergaonkar

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