PMID: 6113355Jun 27, 1981Paper

Pathophysiology of migraine: a new hypothesis

Lancet
G Burnstock

Abstract

Cerebral blood flow is thought to decrease during the preheadache phase of migraine and increase during the headache phase. Most investigations of the pathophysiology of migraine have been concerned with the factors that trigger the preheadache phase. The present hypothesis proposes that, regardless of the triggering factors associated with vasospasm, this will be followed by a common event--namely, reactive hyperaemia due to hypoxia. It is suggested that adenosine triphosphate (ATP), perhaps released from "purinergic" nerves, and its breakdown products adenosine monophosphate (AMP) and adenosine are strong contenders for agents mediating this vasodilatation. ATP is a potent dilator of cerebral vessels and its breakdown products are also dilators. High concentrations of AMP and adenosine have been collected in cerebrospinal fluid during vasodilatation following ischaemia or hypoxia. The presence of ATP and its breakdown products could also explain pain in migraine. These substances stimulate primary afferent nerve terminals in the skin and produce pain in human skin blisters; and nerve profiles that resemble afferent terminals in their ultrastructure have been described in the adventitia of cerebral arteries and in the subarach...Continue Reading

References

May 1, 1978·British Journal of Pharmacology·G BurnstockL Kasakov
Apr 1, 1978·Postgraduate Medical Journal·E S Johnson
Jan 1, 1979·Progress in Neurobiology·E S Vizi
Feb 28, 1975·Brain Research·P Schubert, G W Kreutzberg
Jul 15, 1978·Lancet·C H Hawkes
Dec 2, 1978·Lancet·B P O'Neill, J D Mann
Nov 1, 1979·The Journal of Physiology·T ForresterE M Thomson
Jun 1, 1975·The American Journal of Physiology·R RubioR R CURNISH
Dec 1, 1978·Acta Physiologica Scandinavica·S RehncronaE Westerberg
Apr 1, 1978·British Journal of Pharmacology·T Bleehen
Mar 11, 1976·Pflügers Archiv : European journal of physiology·M Wahl, W Kuschinsky
Dec 15, 1975·Experientia·T J LeeJ A Bevan
Aug 1, 1973·Archives of Neurology·E Skinhoj
Jan 1, 1971·European Journal of Pharmacology·N KolassaM Träm
Feb 1, 1980·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·P Böck
Jan 1, 1980·General Pharmacology·G Burnstock
Aug 1, 1976·Neuroscience·G Burnstock

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Citations

Jun 24, 2008·Purinergic Signalling·Ashwin KumariaGeoffrey Burnstock
Jul 16, 2008·Current Pain and Headache Reports·Robert E Shapiro
Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Burnstock
Jul 14, 1984·Lancet·J M Pearce
Apr 3, 2001·Trends in Pharmacological Sciences·G Burnstock
Aug 1, 1996·Current Opinion in Neurobiology·G Burnstock, J N Wood
Jun 1, 1985·British Medical Journal·R Joseph, F C Rose
Jun 3, 2014·The Journal of Headache and Pain·Flóra Gölöncsér, Beáta Sperlágh
Jul 3, 2016·Purinergic Signalling·Gennady G YegutkinRashid Giniatullin
Jul 2, 2009·Autonomic & Autacoid Pharmacology·G Burnstock
Oct 18, 2005·Pharmacology & Therapeutics·Geoffrey Burnstock
Jun 1, 1982·Cephalalgia : an International Journal of Headache·W K Amery
Nov 26, 1998·Japanese Journal of Pharmacology·M P Abbracchio, G Burnstock
May 11, 2015·Purinergic Signalling·Marek CieślakMichał Komoszyński
Jan 7, 2017·Circulation Research·Geoffrey Burnstock
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Aug 1, 1984·Annals of Neurology·M A Moskowitz
Apr 27, 2019·Frontiers in Cellular Neuroscience·Duygu Koyuncu IrmakFatma Tore
Sep 29, 2020·Frontiers in Cellular Neuroscience·Kseniia KorolevaGuzel Sitdikova
Apr 9, 1998·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R GuieuH Rochat
Oct 1, 1982·Developmental Medicine and Child Neurology·P Tomlin, R Newton
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock
Oct 16, 2018·Frontiers in Cellular Neuroscience·Dilyara NurkhametovaRashid Giniatullin
Apr 3, 1995·The Medical Journal of Australia·S G Brown, G W Waterer
May 1, 1985·Cephalalgia : an International Journal of Headache·H LechnerE Pilger
May 1, 1985·Cephalalgia : an International Journal of Headache·G Burnstock

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