Pathophysiology of salt-sensitive hypertension: a new scope of an old problem

Blood Purification
Martha FrancoBernardo Rodriguez-Iturbe

Abstract

It has been recognized for many years that salt intake is one of the main environmental factors responsible for the development of hypertension. More than 30 years ago, Guyton and co-workers postulated a relationship between blood pressure and natriuresis which maintains sodium balance and extracellular volume; thus an impaired ability of the kidney to excrete sodium requires an increase in blood pressure to increase natriuresis and correct the sodium balance, resulting in hypertension. Currently, the mechanisms responsible for the alterations mentioned above remain under investigation. Among them, microvascular and tubulointerstitial injury induce salt retention and development of salt-sensitive hypertension that appears to be mediated in part by lymphocytes and macrophages infiltrating the tubulointerstitium that produce angiotensin II and stimulate oxidative stress. In the post-angiotensin salt-sensitive hypertension model, angiotensin levels are elevated despite systemic angiotensin II levels being suppressed, and the local angiotensin II levels correlate with the presence of intrarenal inflammation and cortical vasoconstriction. Under these conditions, blockade of the angiotensin II AT1 receptors ameliorate cortical vasoco...Continue Reading

References

Aug 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R E Tracy
Oct 1, 1988·American Journal of Hypertension·B M BrennerS Anderson
Oct 27, 1983·The New England Journal of Medicine·J J CurtisA G Diethelm
May 1, 1996·Current Opinion in Nephrology and Hypertension·M H Weinberger
Nov 1, 1996·American Journal of Hypertension·S Julius, S Nesbitt
Oct 25, 2001·Journal of the American Society of Nephrology : JASN·Martha FrancoJaime Herrera-Acosta
Mar 22, 2002·The New England Journal of Medicine·Richard J JohnsonBernardo Rodriguez-Iturbe
Aug 23, 2002·Journal of the American Society of Nephrology : JASN·Akira NishiyamaL Gabriel Navar
Dec 6, 2002·Journal of the American Society of Nephrology : JASN·Cristina BarlassinaGiuseppe Bianchi
Jan 10, 2003·The New England Journal of Medicine·Gunhild KellerKerstin Amann
Apr 17, 2003·Current Opinion in Nephrology and Hypertension·Takahiko NakagawaRichard J Johnson
Jul 11, 2003·Cardiology in Review·John KanellisRichard J Johnson
Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Jose HerreraBernardo Rodriguez-Iturbe

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Citations

Jun 7, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Eberhard Ritz, Otto Mehls
Sep 3, 2010·The British Journal of Nutrition·Catherine E HugginsCaryl A Nowson
Mar 11, 2011·Clinical and Experimental Pharmacology & Physiology·Katsuyuki Ando, Megumi Fujita
Jun 26, 2009·American Journal of Physiology. Renal Physiology·Marlina ManhianiJohn D Imig
Jul 16, 2014·Archivos de cardiología de México·Yaniel Castro TorresIldiko María Garrido Bősze
Nov 21, 2012·Archivos de cardiología de México·Rafael González-Toledo, Martha Franco

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