Abstract
Because little is known about the pathophysiology of invasive pulmonary aspergillosis (IPA), we examined changes in pulmonary and general physiology during this disease in an animal model. In a model of fatal left-sided IPA, 19 persistently neutropenic rats were monitored for clinical signs including body temperature, body weight and respiratory distress. A separate group of nine rats with IPA was used for measurements of arterial blood pressure, arterial O2 and CO2 pressure, lung compliance and surfactant function. Body temperature and body weight decreased, whereas respiratory distress increased during progression of the disease. Compared to uninfected controls, in rats with IPA arterial blood pressure and lung compliance were significantly lower, and left lung minimal surface tension was significantly higher. Right lung surfactant function was not affected. Arterial O2 and CO2 pressures were not different between rats with IPA and uninfected controls. Infection with Aspergillus fumigatus in neutropenic rats resulted in hypothermia, body weight loss and respiratory distress. Loss of left lung function was probably compensated by the uninfected right lung, even in a late stage of the disease. Circulatory failure was a major fe...Continue Reading
References
Jun 1, 1991·Canadian Journal of Physiology and Pharmacology·P J ScarpaceS E Borst
Jan 1, 1991·Intensive Care Medicine·E P EijkingB Lachmann
Aug 1, 1990·Annals of Internal Medicine·J E ParrilloF P Ognibene
Mar 1, 1989·The Journal of Experimental Medicine·C NatansonJ E Parrillo
Jan 1, 1987·Comparative Biochemistry and Physiology. A, Comparative Physiology·K Y Lagerspetz, T Väätäinen
Jul 1, 1994·Shock·G SchlagI Haller
Sep 1, 1994·Mycoses·M von EiffJ van de Loo
Jan 1, 1994·Mycoses·A R KhosraviM Mahmoudi
Jan 1, 1994·Intensive Care Medicine·B LachmannD Gommers
Jun 1, 1993·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·V KrcméryL Drgona
Apr 1, 1993·Critical Care Medicine·D GommersB Lachmann
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·A BouttenM Aubier
May 1, 1996·American Journal of Respiratory and Critical Care Medicine·T TerashimaM Kanazawa
Jun 1, 1996·British Journal of Pharmacology·A van 't VeenB Lachmann
Jan 1, 1997·Critical Care Medicine·G M Matuschak, A J Lechner
Apr 8, 1998·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·M J Naughton, R T Anderson
Jun 13, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D W Denning
Jan 8, 1999·Journal of Medical Microbiology·R EvansD O Ho-Yen
Jan 19, 1999·The Journal of Infection·Y RoubyM Huerre
Aug 24, 1999·Infection and Immunity·M J AllenR J Mason
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S J LinS M Teutsch
Apr 12, 2001·Critical Care : the Official Journal of the Critical Care Forum·R Naeije, S Brimioulle
Feb 2, 2002·Nuclear Medicine and Biology·Martin J BeckerIrma A J M Bakker-Woudenberg
May 11, 2002·The Journal of Antimicrobial Chemotherapy·Martin J BeckerIrma A J M Bakker-Woudenberg
Aug 15, 2003·The Journal of Antimicrobial Chemotherapy·Martin J BeckerIrma A J M Bakker-Woudenberg
Citations
Feb 25, 2009·Antimicrobial Agents and Chemotherapy·Wendy W J van de SandeIrma A J M Bakker-Woudenberg
Aug 8, 2008·Bioinformation·Willy Valdivia-Granda
Apr 23, 2009·Mycoses·J ChandenierD Richard-Lenoble
Aug 2, 2005·FEMS Immunology and Medical Microbiology·Stéphane Bretagne, Jean-Marc Costa
Aug 17, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Stéphane Bretagne, Jean-Marc Costa
Jul 26, 2017·PloS One·Jeannine M RefosWendy W J van de Sande
Jun 1, 2017·Frontiers in Microbiology·Guillaume Desoubeaux, Carolyn Cray
May 27, 2021·Studies in Mycology·A ArastehfarM Hoenigl