Pathway-Based Drug Repositioning for Breast Cancer Molecular Subtypes

Frontiers in Pharmacology
Raúl A Mejía-PedrozaEnrique Hernández-Lemus

Abstract

Breast cancer is a major public health problem which treatment needs new pharmacological options. In the last decades, during the postgenomic era new theoretical and technological tools that give us novel and promising ways to address these problems have emerged. In this work, we integrate several tools that exploit disease-specific experimental transcriptomic results in addition to information from biological and pharmacological data bases obtaining a contextual prioritization of pathways and drugs in breast cancer subtypes. The usefulness of these results should be evaluated in terms of drug repurposing in each breast cancer molecular subtype therapy. In favor of breast cancer patients, this methodology could be further developed to provide personalized treatment schemes. The latter are particularly needed in those breast cancer subtypes with limited therapeutic options or those who have developed resistance to the current pharmacological schemes.

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Citations

Nov 2, 2019·Genes·Enrique Hernández-LemusSoledad Ochoa
Jun 1, 2020·Journal of Cancer Research and Clinical Oncology·Diana E Alvarez-SuarezM Verónica Ponce-Castañeda
Sep 25, 2019·Anti-cancer Agents in Medicinal Chemistry·Ümmügülsüm TanmanDemet Cansaran-Duman
Feb 15, 2019·Frontiers in Immunology·Tadeo Enrique Velazquez-CaldelasEnrique Hernandez-Lemus
Jul 1, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rammohan ShuklaRobert E Mccullumsmith
Mar 3, 2020·Frontiers in Oncology·Erandi A Serrano-CarbajalEnrique Hernández-Lemus
Jan 7, 2021·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Brenda Cabrera-MendozaHumberto Nicolini
Sep 25, 2019·Seminars in Cancer Biology·Sadhna AggarwalSubash Chandra Gupta
Jun 7, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bárbara CostaNuno Vale
Apr 6, 2021·Frontiers in Genetics·Soledad OchoaEnrique Hernández-Lemus
Jun 15, 2021·Interface Focus·Guillermo de Anda-JáureguiEnrique Hernández-Lemus
May 6, 2019·Journal of Medicinal Chemistry·Gaochan WuPeng Zhan

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Methods Mentioned

BETA
RNAseq

Software Mentioned

METABRIC
limma
Pathifier
DeSeq2
MapSlice
RSEM4
Emacs speak
RDGIdb

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