Pathway of PPAR-gamma coactivators in thermogenesis: a pivotal traditional Chinese medicine-associated target for individualized treatment of rheumatoid arthritis

Oncotarget
Yanqiong ZhangNa Lin

Abstract

Traditional Chinese medicine (TCM) syndromes have been regarded as the crucial clinical manifestations for individualized diagnosis and treatment of complex diseases, including rheumatoid arthritis (RA) and cancer. Especially, RA patients are classified into cold and hot syndromes with different clinical manifestations, interventions and molecular mechanisms. Better effectiveness of a classic cold syndrome-specific herbal formula Wu-tou decoction (WTD) has been achieved. To explore molecular mechanisms of syndrome-specific formulae is of great clinical significance to improve the effectiveness and pertinence of treatment for the complex diseases with personalized conditions. However, the scientific basis of WTD treatment on RA with the cold syndrome remains unclear. Here, we predicted the putative targets for composite compounds contained in WTD using drugCIPHER-CS and constructed a WTD herbs-putative targets-RA related genes network. Next, a list of major WTD targets was identified based on their topological features, including the degree, node betweenness, closeness and k-coreness in the above pharmacological network. Importantly, pathway enrichment analysis revealed that these major WTD targets were significantly associated ...Continue Reading

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Citations

Apr 20, 2017·Oncotarget·Wei LiuBingjin Li
Aug 1, 2019·International Journal of Molecular Medicine·Hui JiangWei-Ping Li
Feb 1, 2020·Journal of Pharmaceutical and Biomedical Analysis·Yong-Sheng WuHua Yang
Feb 1, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xia MaoNa Lin

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Methods Mentioned

BETA
ELISA

Software Mentioned

CIPHER
Navigator
drugCIPHER
SPSS
BioCarTa
CS

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