Pathways crossing mammalian and plant sulfenomic landscapes

Free Radical Biology & Medicine
Jingjing HuangJoris Messens

Abstract

Reactive oxygen species (ROS) and especially hydrogen peroxide, are potent signaling molecules that activate cellular defense responses. Hydrogen peroxide can provoke reversible and irreversible oxidative posttranslational modifications on cysteine residues of proteins that act in diverse signaling circuits. The initial oxidation product of cysteine, sulfenic acid, has emerged as a biologically relevant posttranslational modification, because it is the primary sulfur oxygen modification that precedes divergent series of additional adaptations. In this review, we focus on the functional consequences of sulfenylation for both mammalian and plant proteins. Furthermore, we created compendia of sulfenylated proteins in human and plants based on mass spectrometry experiments, thereby defining the current plant and human sulfenomes. To assess the evolutionary conservation of sulfenylation, the sulfenomes of human and plants were compared based on protein homology. In total, 185 human sulfenylated proteins showed homology to sulfenylated plant proteins and the conserved sulfenylation targets participated in specific biological pathways and metabolic processes. Comprehensive functional studies of sulfenylation remains a future challenge...Continue Reading

Citations

Sep 12, 2018·Bioscience Reports·Véronique Larosa, Claire Remacle
Nov 6, 2018·The Plant Journal : for Cell and Molecular Biology·Barbara De SmetFrank Van Breusegem
Apr 21, 2019·The Plant Journal : for Cell and Molecular Biology·Patrick WillemsKris Gevaert
Oct 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jingjing HuangJoris Messens
Feb 29, 2020·Journal of Experimental Botany·Haiyan DingShengchun Li
Oct 5, 2019·International Journal of Molecular Sciences·Luisa M SandalioMaria C Romero-Puertas
Dec 19, 2020·Frontiers in Cell and Developmental Biology·Xiaru LyuLei Li
Jan 30, 2021·Molecular and Biochemical Parasitology·Susanne SchipperJude M Przyborski
Dec 20, 2020·Antioxidants·Maria-Armineh TossounianIvan Gout
Feb 16, 2021·Plant Physiology·Luisa M SandalioMaria C Romero-Puertas
Apr 2, 2021·Plant Physiology·Patrick WillemsJingjing Huang

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