Pathways for Contextual Memory: The Primate Hippocampal Pathway to Anterior Cingulate Cortex.

Cerebral Cortex
Jingyi WangH Barbas

Abstract

The anterior cingulate cortex (ACC) is one of the few prefrontal areas that receives robust direct hippocampal terminations. This pathway may enable current context and past experience to influence goal-directed actions and emotional regulation by prefrontal cortices. We investigated the still ill-understood organization of the pathway from anterior hippocampus to ACC (A24a, A25, A32) to identify laminar termination patterns and their postsynaptic excitatory and inhibitory targets from system to synapse in rhesus monkeys. The densest hippocampal terminations targeted posterior A25, a region that is involved in affective and autonomic regulation. Hippocampal terminations innervated mostly excitatory neurons (~90%), suggesting strong excitatory effects. Among the smaller fraction of inhibitory targets, hippocampal terminations in A25 preferentially innervated calretinin neurons, a pattern that differs markedly from rodents. Further, hippocampal terminations innervated spines with D1 receptors, particularly in the deep layers of A25, where D1 receptors are enriched in comparison with the upper layers. The proximity of hippocampal terminations to D1 receptors may enable dopamine to enhance information transfer from the hippocampus ...Continue Reading

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Citations

May 14, 2021·Neuroscience and Biobehavioral Reviews·Laith AlexanderAllan H Young
Aug 8, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Todd M Preuss, Steven P Wise
Aug 18, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margaux M KenwoodHelen Barbas
Oct 15, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sharon M Kolk, Pasko Rakic

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