PMID: 8967429May 1, 1996Paper

Pathways for K+ transport across the bovine articular chondrocyte membrane and their sensitivity to cell volume

The American Journal of Physiology
A C HallS Rashidbigi

Abstract

The contributions of various K+ transport pathways in bovine chondrocytes isolated from articular cartilage and their responses to changes in cell volume have been studied. K+(86Rb+) uptake mediated by the Na(+)-K(+) pump and Na(+)-K(+)-2Cl- cotransporter were stimulated by cell shrinkage, the latter as part of the regulatory volume increases (RVI) response, the former as an indirect effect resulting from the rise in intracellular Na+ concentration during RVI. For both transporters, there was an increase in the maximum velocity with no detectable effect on the Michaelis constant. There was no evidence for volume-sensitive K+ transport mediated by the K(+)-Cl- cotransporter, or Ca(2+)-activated K+ channels. However, chondrocyte swelling stimulated a ouabain- and bumetanide-insensitive K+ flux sensitive to pimozide and other drugs, which exhibited some of the properties of the relatively nonspecific volume-sensitive "osmolyte" channel described in other cell types.

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Citations

Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P G Bush, A C Hall
Jul 24, 2003·Equine Veterinary Journal·R J WilkinsJ S Gibson
Sep 13, 2007·Pflügers Archiv : European journal of physiology·J S GibsonR J Wilkins
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Rebecca LewisRichard Barrett-Jolley
Feb 16, 2005·The Journal of Membrane Biology·N C AdragnaP K Lauf
Apr 27, 2007·Journal of Cellular Physiology·Victoria L SimpkinAndrew C Hall
Jun 15, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K WuertzC Neidlinger-Wilke
Oct 16, 2012·Channels·Ali MobasheriRichard Barrett-Jolley
Jun 24, 2010·Current Opinion in Nephrology and Hypertension·Jens Titze, Agnes Machnik
Jul 12, 2002·Journal of Cellular Biochemistry·Clare E YellowleyHenry J Donahue
Apr 25, 2001·Journal of Cellular Physiology·P G Bush, A C Hall
Jul 4, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hiroshi KajiyaKoji Okabe
Sep 2, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sang-Kuy HanWalter Herzog
Feb 18, 2011·Journal of Cellular Physiology·Rebecca LewisRichard Barrett-Jolley
Jun 18, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Sang-Bing OngMark J P Kerrigan
Jul 25, 2000·Acta Physiologica Scandinavica·N YamazakiR J Wilkins
Aug 10, 2006·Journal of Cellular Physiology·Mark J P KerriganAndrew C Hall
May 18, 1999·The American Journal of Physiology·W C O'Neill
Aug 30, 2012·British Journal of Pharmacology·R LewisR Barrett-Jolley
Feb 18, 2010·Journal of Cellular Physiology·Ali MobasheriRichard Barrett-Jolley
Aug 12, 2018·Journal of Biomechanical Engineering·Jay C HouGerard A Ateshian
Aug 14, 2012·Journal of Biomechanics·Sang-Kuy HanWalter Herzog
Sep 15, 2007·Osteoarthritis and Cartilage·M J P Kerrigan, A C Hall

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